Evidence map›Paper›PMID 37611111›Full record

ArticleScience advances2023

Amphiregulin couples IL1RL1

Runzi Sun, Hongyu Zhao, David Shihong Gao, Andrew Ni, Haochen Li, Lujia Chen, Xinghua Lu, Kong Chen, Binfeng Lu

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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    Review
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  10. Smoking promotes colorectal cancer via the CKAP2L/AREG axis.International journal of oncology · 2026
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  12. Specific depletion of TIGITJournal for immunotherapy of cancer · 2026
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Runzi SunDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-4579-8648
Hongyu ZhaoCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
David Shihong GaoDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-8210-2534
Andrew NiDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0003-4090-7187
Haochen LiDepartment of Biomedical informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0003-0104-8818
Lujia ChenDepartment of Biomedical informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Xinghua LuDepartment of Biomedical informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-8599-2269
Kong ChenDepartment of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Binfeng LuDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-7822-5950
University of Pittsburgh · USHackensack Meridian Health · US

Funding

Interpretable deep learning models for translational medicine RenewalR01LM012011 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tanner J. Freeman, XINGHUA LU · 2015 to 2026
$3.6M
Study of the IL-33-driven immune cell organization underpinning responses to immune checkpoint blockade cancer therapyR01CA254274 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LU, BINFENG · 2021 to 2025
$1.9M
Study of Interleukin 33 as a new immunotherapy of lung cancerR01CA239716 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, SONG, LU, BINFENG · 2019 to 2023
$1.8M
NCI NIH HHS R01 CA239716NCI NIH HHS R01 CA254274NLM NIH HHS R01 LM012011
6 · The paper itself

Abstract

Regulatory T (T

Indexed as

Cancer-Associated FibroblastsT-Lymphocytes, RegulatoryAmphiregulinCarcinogenesisCell Transformation, NeoplasticErbB ReceptorsHumansInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Tumor MicroenvironmentAmphiregulinErbB ReceptorsIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinInterleukin-33

Identifiers

PMID37611111
PMCPMC10446484
OpenAlexW4386112164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.