Evidence map›Paper›PMID 37611110›Full record

ArticleScience advances2023

Fluoride permeation mechanism of the Fluc channel in liposomes revealed by solid-state NMR.

Jin Zhang, Dan Song, Florian Karl Schackert, Juan Li, Shengqi Xiang, Changlin Tian, Weimin Gong, Paolo Carloni, Mercedes Alfonso-Prieto, Chaowei Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Fluorinated Protein-Ligand Complexes: A Computational Perspective.The journal of physical chemistry. B · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jin ZhangDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Center for BioAnalytical Chemistry, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China.ORCID 0000-0001-9753-5180
Dan SongDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Center for BioAnalytical Chemistry, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China.ORCID 0000-0003-3686-9042
Florian Karl SchackertInstitute for Advanced Simulations (IAS-5) and Institute of Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0001-6028-3717
Juan LiDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Center for BioAnalytical Chemistry, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China.
Shengqi XiangDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Center for BioAnalytical Chemistry, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China.ORCID 0000-0002-6874-4925
Changlin TianDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Center for BioAnalytical Chemistry, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China.
Weimin GongDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Center for BioAnalytical Chemistry, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China.ORCID 0000-0002-6723-1298
Paolo CarloniInstitute for Advanced Simulations (IAS-5) and Institute of Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0002-9010-0149
Mercedes Alfonso-PrietoInstitute for Advanced Simulations (IAS-5) and Institute of Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0003-4509-4517
Chaowei ShiDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Center for BioAnalytical Chemistry, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China.ORCID 0000-0002-0024-1096
University of Science and Technology of China · CNForschungszentrum Jülich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid-state nuclear magnetic resonance (ssNMR) methods can probe the motions of membrane proteins in liposomes at the atomic level and propel the understanding of biomolecular processes for which static structures cannot provide a satisfactory description. In this work, we report our study on the fluoride channel Fluc-Ec1 in phospholipid bilayers based on ssNMR and molecular dynamics simulations. Previously unidentified fluoride binding sites in the aqueous vestibules were experimentally verified by

Indexed as

FluoridesLiposomesMagnetic Resonance ImagingMagnetic Resonance SpectroscopyWaterFluoridesLiposomesWater

Identifiers

PMID37611110
PMCPMC10446490
OpenAlexW4386088939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.