Evidence map›Paper›PMID 37610247›Full record

ArticleThe Plant cell2023

Pathogen-induced m6A dynamics affect plant immunity.

Wil Prall, Arsheed H Sheikh, Jeremie Bazin, Jean Bigeard, Marilia Almeida-Trapp, Martin Crespi, Heribert Hirt, Brian D Gregory

Open access · greenAbstract read
In one paragraph

Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. CDS-localized mNature plants · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Role of mEpigenomes · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. RNA-binding proteins orchestrating immunity in plants.The Plant journal : for cell and molecular biology · 2025
    Review
  13. Article
  14. Article
  15. An mNature communications · 2025
    Article
  16. RNA mNature plants · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. YTHDF2-mediated mFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Wil PrallDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104,USA.ORCID 0000-0003-3270-7636
Arsheed H SheikhCenter for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900,Saudi Arabia.ORCID 0000-0003-1883-5439
Jeremie BazinCNRS, INRA, Institute of Plant Sciences Paris-Saclay IPS2, Universite Paris Sud, Universite Evry, Universite Paris-Diderot, Sorbonne Paris-Cite, Universite Paris-Saclay, 91190 Gif-sur-Yvette,France.ORCID 0000-0001-7713-5278
Jean BigeardCNRS, INRA, Institute of Plant Sciences Paris-Saclay IPS2, Universite Paris Sud, Universite Evry, Universite Paris-Diderot, Sorbonne Paris-Cite, Universite Paris-Saclay, 91190 Gif-sur-Yvette,France.ORCID 0000-0002-4762-8423
Marilia Almeida-TrappCenter for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900,Saudi Arabia.ORCID 0000-0002-9980-322X
Martin CrespiCNRS, INRA, Institute of Plant Sciences Paris-Saclay IPS2, Universite Paris Sud, Universite Evry, Universite Paris-Diderot, Sorbonne Paris-Cite, Universite Paris-Saclay, 91190 Gif-sur-Yvette,France.ORCID 0000-0002-5698-9482
Heribert HirtCenter for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900,Saudi Arabia.ORCID 0000-0003-3119-9633
Brian D GregoryDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104,USA.ORCID 0000-0001-7532-0138
Université Paris-Sud · FRKing Abdullah University of Science and Technology · SAPennsylvania State University · USUniversity of Vienna · AT

Funding

KAUST International Program OCRF-2014-CRG4King Abdullah University of Science and Technology BAS/1/1062-01-01Saclay Plant Sciences-SPS ANR-17-EUR-0007United States National Science Foundation IOS-2023310
6 · The paper itself

Abstract

Posttranscriptional regulation of mRNA mediated by methylation at the N6 position of adenine (N6-methyladenosine [m6A]) has profound effects on transcriptome regulation in plants. Focused studies across eukaryotes offer glimpses into the processes governed by m6A throughout developmental and disease states. However, we lack an understanding of the dynamics and the regulatory potential of m6A during biotic stress in plants. Here, we provide a comprehensive look into the effects of m6A on both the short-term and long-term responses to pathogen signaling in Arabidopsis (Arabidopsis thaliana). We demonstrate that m6A-deficient plants are more resistant to bacterial and fungal pathogen infections and have altered immune responses. Furthermore, m6A deposition is specifically coordinated on transcripts involved in defense and immunity prior to and proceeding the pathogen signal flagellin. Consequently, the dynamic modulation of m6A on specific stress-responsive transcripts is correlated with changes in abundance and cleavage of these transcripts. Overall, we show that the m6A methylome is regulated prior to and during simulated and active pathogen stress and functions in the coordination and balancing of normal growth and pathogen responses.

Indexed as

ArabidopsisGene Expression RegulationPlant ImmunityAdenosineMethylationPlantsRNA, MessengerTranscriptomeAdenosineN-methyladenosineRNA, Messenger

Identifiers

PMID37610247
PMCPMC10615206
OpenAlexW4386084425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.