Evidence map›Paper›PMID 37610224›Full record

ArticleAntimicrobial agents and chemotherapy2023

Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and

Ifeanyichukwu E Eke, John T Williams, Elizabeth R Haiderer, Veronica J Albrecht, Heather M Murdoch, Bassel J Abdalla, Robert B Abramovitch

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genetic and Cheminformatic Characterization ofACS infectious diseases · 2025
    Article
  5. Genomic Insight into Primary Adaptation ofAntibiotics (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ifeanyichukwu E EkeDepartment of Microbiology and Molecular Genetics, Michigan State University , East Lansing, Michigan, USA.
John T WilliamsDepartment of Microbiology and Molecular Genetics, Michigan State University , East Lansing, Michigan, USA.ORCID 0000-0002-2742-1636
Elizabeth R HaidererDepartment of Microbiology and Molecular Genetics, Michigan State University , East Lansing, Michigan, USA.
Veronica J AlbrechtDepartment of Microbiology and Molecular Genetics, Michigan State University , East Lansing, Michigan, USA.
Heather M MurdochDepartment of Microbiology and Molecular Genetics, Michigan State University , East Lansing, Michigan, USA.
Bassel J AbdallaDepartment of Microbiology and Molecular Genetics, Michigan State University , East Lansing, Michigan, USA.
Robert B AbramovitchDepartment of Microbiology and Molecular Genetics, Michigan State University , East Lansing, Michigan, USA.ORCID 0000-0002-4119-4169
Michigan State University · US

Funding

Treatments for Nipah Virus InfectionU54AI057159 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CLARDY, JON · 2003 to 2013
$113.7M
Integrative Pharmacological Sciences Training Program (IPSTP)T32GM142521 · NIGMS · MICHIGAN STATE UNIVERSITY · PI ANNE M. DORRANCE, Gina Marie Leinninger · 2021 to 2026
$2.4M
Screening for inhibitors of M. tuberculosis persistence-related lipid metabolismR21AI105867 · NIAID · MICHIGAN STATE UNIVERSITY · PI ABRAMOVITCH, ROBERT B · 2013 to 2014
$392k
Characterizing new M. tuberculosis inhibitors discovered in the Molecular Libraries Small Molecule RepositoryR03AI153454 · NIAID · MICHIGAN STATE UNIVERSITY · PI ABRAMOVITCH, ROBERT B · 2020 to 2021
$149k
NIAID NIH HHS R03 AI153454NIAID NIH HHS R21 AI105867NIAID NIH HHS U54 AI057159NIGMS NIH HHS T32 GM142521
6 · The paper itself

Abstract

Nitro-containing compounds have emerged as important agents in the control of tuberculosis (TB). From a whole-cell high-throughput screen for

Indexed as

NitrofuransNitroimidazolesAnimalsBacterial LoadMiceNitro CompoundsNitro CompoundsNitrofuransNitroimidazolespretomaniddeazaflavin-dependent nitroreductaseDprE1Mycobacterium abscessusMycobacterium tuberculosisnitrofuran

Identifiers

PMID37610224
PMCPMC10508139
OpenAlexW4386084620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.