Evidence map›Paper›PMID 37610144›Full record

ArticlemAbs

A machine learning strategy for the identification of key

Andrew B Waight, David Prihoda, Rojan Shrestha, Kevin Metcalf, Marc Bailly, Marco Ancona, Talal Widatalla, Zachary Rollins, Alan C Cheng, Danny A Bitton and 1 more

Abstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrew B WaightDiscovery Biologics, Protein Sciences, Merck & Co., Inc, South San Francisco, CA, USA.ORCID 0000-0002-4110-1452
David PrihodaDiscovery Informatics, MSD Czech Republic s.r.o, Prague, Czech Republic.
Rojan ShresthaDiscovery Biologics, Protein Sciences, Merck & Co., Inc, South San Francisco, CA, USA.
Kevin MetcalfDiscovery Biologics, Protein Sciences, Merck & Co., Inc, South San Francisco, CA, USA.
Marc BaillyDiscovery Biologics, Protein Sciences, Merck & Co., Inc, South San Francisco, CA, USA.
Marco AnconaDiscovery Informatics, MSD Czech Republic s.r.o, Prague, Czech Republic.
Talal WidatallaComputational and Structural Chemistry, Merck & Co., Inc, South San Francisco, CA, USA.
Zachary RollinsComputational and Structural Chemistry, Merck & Co., Inc, South San Francisco, CA, USA.
Alan C ChengComputational and Structural Chemistry, Merck & Co., Inc, South San Francisco, CA, USA.
Danny A BittonDiscovery Informatics, MSD Czech Republic s.r.o, Prague, Czech Republic.
Laurence Fayadat-DilmanDiscovery Biologics, Protein Sciences, Merck & Co., Inc, South San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of favorable biophysical properties for protein therapeutics as part of developability assessment is a crucial part of the preclinical development process. Successful prediction of such properties and bioassay results from calculated

Indexed as

Antibodies, MonoclonalImmunoglobulin GHumansMachine LearningAntibodies, MonoclonalImmunoglobulin GBiophysicalcomputationaldescriptorsdevelopabilityIgG1machine learning

Identifiers

PMID37610144
PMCPMC10448975

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.