ArticleEMBO reports2023
Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice.
Article in EMBO reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring.Frontiers in immunology · 2026Article
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- Exposure to Human Immunodeficiency Virus Is Associated With Altered Composition of Maternal Microchimeric T Cells in Infants.The Journal of infectious diseases · 2025Article
- Micro-to multi-chimerism: the multiple facets of a singular phenomenon.Seminars in immunopathology · 2025Review
- Maternal microchimeric cell trafficking and its biological consequences depend on the onset of inflammation at the feto-maternal interface.Seminars in immunopathology · 2025Review
- Deciphering the Role of Maternal Microchimerism in Offspring Autoimmunity: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- From Womb to World: Exploring the Immunological Connections between Mother and Child.ImmunoHorizons · 2024Review
- The 'communicatome' of pregnancy: spotlight on cellular and extravesicular chimerism.EMBO molecular medicine · 2024Review
- Pregnancy induced displacement of preexisting microchimeric cells in the absence of maternal B and T cells.Frontiers in immunology · 2024Article
- Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice.EMBO reports · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant Listeria monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally-derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.