ArticleJournal of the American Heart Association2023
Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01555411 (Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Pooled it
- Application of the Carotid Plaque-RADS Classification System in Ultrasound: Inter- and Intra-Observer Agreement Analysis and Learning Curve Analysis.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Multimodal ultrasound and computed tomography imaging may improve the discrimination between symptomatic and asymptomatic patients with carotid stenosis.American heart journal plus : cardiology research and practice · 2026Article
- Resting Ultrasound Coronary Flow Velocity and Carotid Plaque Improve Clinical Risk Stratification in Asymptomatic Adults Undergoing Cardiovascular Screening.Diagnostics (Basel, Switzerland) · 2026Article
- Carotid plaque burden and hemodynamic alterations are associated with domain-specific cognitive impairment in community-dwelling older adults.Scientific reports · 2026Article
- Integrating genetic and imaging information to enhance cardiovascular risk stratification: rationale and design of the CVRISK-IT randomized controlled trial.European heart journal. Quality of care & clinical outcomes · 2026Article
- Carotid plaque burden across the glycaemic spectrum: a cross-sectional study.BMC endocrine disorders · 2026Article
- Carotid Plaques and Type 2 Diabetes as Predictors of Cardiovascular Events and Mortality: Insights from the LitHiR Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Subclinical diastolic dysfunction and its association with disease activity in patients with rheumatoid arthritis.Internal and emergency medicine · 2026Article
- Routine Handheld Carotid Ultrasonography for Cardiovascular Risk Stratification and Primary Prevention Treatment Decisions in a Contemporary Middle-Aged General Population.Journal of the American Heart Association · 2026Article
- Risk prediction and prevention in patients with advanced subclinical atherosclerosis.BMC cardiovascular disorders · 2026Review
- Uncovering the similarities of lipidome-wide markers of carotid artery plaque and metabolic dysfunction-associated fatty liver disease: the Young Finns study.Scientific reports · 2026Article
- Genetic predisposition to coffee consumption and the association with the early risk of atherosclerosis.Scientific reports · 2026Article
- Observational
- Association between a novel ultrasound-based measure of plaque burden and cardiovascular risk: the P-SONAR study.Quantitative imaging in medicine and surgery · 2026Article
- Association between socioeconomic variables and carotid plaque in middle-aged adults: data from the Akershus Cardiac Examination (ACE) 1950 Study.Open heart · 2026Article
- Age Modifies the Association Between Smoking and Carotid Artery Plaque: A Cross-Sectional Study in Non-Diabetic Adults.International journal of general medicine · 2026Article
- Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques.PloS one · 2026Article
- Development and validation of a cross-sectional risk screening nomogram for carotid plaque based on routine health examination data and the triglyceride-glucose-waist-to-hip ratio.Frontiers in endocrinology · 2026Article
- Association between systemic inflammation indices and carotid plaques in acute coronary syndrome.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background We aimed to explore the predictive value of the carotid plaque score, compared with the Systematic Coronary Risk Evaluation 2 (SCORE2) risk prediction algorithm, on incident ischemic stroke and major adverse cardiovascular events and establish a prognostic cutoff of the carotid plaque score. Methods and Results In the prospective ACE 1950 (Akershus Cardiac Examination 1950 study), carotid plaque score was calculated with ultrasonography at inclusion in 2012 to 2015. The largest plaque diameter in each extracranial segment of the carotid artery on both sides was scored from 0 to 3 points. The sum of points in all segments provided the carotid plaque score. The cohort was followed up by linkage to national registries for incident ischemic stroke and major adverse cardiovascular events (nonfatal ischemic stroke, nonfatal myocardial infarction, and cardiovascular death) throughout 2020. Carotid plaque score was available in 3650 (98.5%) participants, with mean±SD age of 63.9±0.64 years at inclusion. Only 462 (12.7%) participants were free of plaque, and and 970 (26.6%) had a carotid plaque score of >3. Carotid plaque score predicted ischemic stroke (hazard ratio [HR], 1.25 [95% CI, 1.15-1.36]) and major adverse cardiovascular events (HR, 1.21 [95% CI, 1.14-1.27]) after adjustment for SCORE2 and provided strong incremental prognostic information to SCORE2. The best cutoff value of carotid plaque score for ischemic stroke was >3, with positive predictive value of 2.5% and negative predictive value of 99.3%. Conclusions The carotid plaque score is a strong predictor of ischemic stroke and major adverse cardiovascular events, and it provides incremental prognostic information to SCORE2 for risk prediction. A cutoff score of >3 seems to be suitable to discriminate high-risk subjects. Registration Information clinicaltrials.gov. Identifier: NCT01555411.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.