Evidence map›Paper›PMID 37609868›Full record

ArticleAging cell2023

Accelerated aging in mice with astrocytic redox imbalance as a consequence of SOD2 deletion.

Konstantinos Tsesmelis, Gandhari Maity-Kumar, Dana Croner, Jasmin Sprissler, Miltiadis Tsesmelis, Tabea Hein, Bernd Baumann, Thomas Wirth

Abstract read
In one paragraph

Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Konstantinos TsesmelisInstitute of Physiological Chemistry, University of Ulm, Ulm, Germany.ORCID 0000-0001-7315-5562
Gandhari Maity-KumarInstitute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Dana CronerInstitute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Jasmin SprisslerInstitute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Miltiadis TsesmelisInstitute of Physiological Chemistry, University of Ulm, Ulm, Germany.ORCID 0000-0002-7438-580X
Tabea HeinInstitute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Bernd BaumannInstitute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Thomas WirthInstitute of Physiological Chemistry, University of Ulm, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging of the central nervous system (CNS) leads to motoric and cognitive decline and increases the probability for neurodegenerative disease development. Astrocytes fulfill central homeostatic functions in the CNS including regulation of immune responses and metabolic support of neurons and oligodendrocytes. In this study, we investigated the effect of redox imbalance in astrocytes by using a conditional astrocyte-specific SOD2-deficient mouse model (SOD2

Indexed as

AgingAstrocytesNeurodegenerative DiseasesAnimalsCentral Nervous SystemMiceOxidation-ReductionagingastrocytesbrainCNSmotoric impairmentoxidative stresspremature agingSOD2

Identifiers

PMID37609868
PMCPMC10497807

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.