ArticleJournal of neurophysiology2023
Single-neuron and population measures of neuronal activity in working memory tasks.
Article in Journal of neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Repeatable, low-drift recordings in behaving nonhuman primates using flexible microelectrodes.Nature communications · 2026Article
- Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026Article
- Working memory expedites the processing of visual signals within the extrastriate cortex.iScience · 2024Article
- Brain-wide human oscillatory local field potential activity during visual working memory.iScience · 2024Article
- Contributions of narrow- and broad-spiking prefrontal and parietal neurons on working memory tasks.Frontiers in systems neuroscience · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Information represented in working memory is reflected in the firing rate of neurons in the prefrontal cortex and brain areas connected to it. In recent years, there has been an increased realization that population measures capture more accurately neural correlates of cognitive functions. We examined how single neuron firing in the prefrontal and posterior parietal cortex of two male monkeys compared with population measures in spatial working memory tasks. Persistent activity was observed in the dorsolateral prefrontal and posterior parietal cortex and firing rate predicted working memory behavior, particularly in the prefrontal cortex. These findings had equivalents in population measures, including trajectories in state space that became less separated in error trials. We additionally observed rotations of stimulus representations in the neuronal state space for different task conditions, which were not obvious in firing rate measures. These results suggest that population measures provide a richer view of how neuronal activity is associated with behavior, largely confirming that persistent activity is the core phenomenon that maintains visual-spatial information in working memory.
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