Evidence map›Paper›PMID 37609446›Full record

ArticleiScience2022

Musculoskeletal modeling of sprawling and parasagittal forelimbs provides insight into synapsid postural transition.

Robert J Brocklehurst, Philip Fahn-Lai, Sophie Regnault, Stephanie E Pierce

Abstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  8. Soft tissue constraints on joint mobility in the avian shoulder.The Journal of experimental biology · 2025
    Article
  9. Article
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  13. Tibial Biomechanics and Adaptive Response to Mechanical Stimuli in the Green Iguana.Integrative organismal biology (Oxford, England) · 2025
    Article
  14. Article
  15. Article
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  18. Functional Anatomy of the Thoracic Limb of the Komodo Dragon (Animals : an open access journal from MDPI · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert J BrocklehurstMuseum of Comparative Zoology and Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 01239, USA.
Philip Fahn-LaiMuseum of Comparative Zoology and Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 01239, USA.
Sophie RegnaultMuseum of Comparative Zoology and Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 01239, USA.
Stephanie E PierceMuseum of Comparative Zoology and Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 01239, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sprawling-parasagittal postural shift was a major transition during synapsid evolution, underpinned by reorganization of the forelimb, and considered key to mammalian ecological diversity. Determining when and how this transition occurred in the fossil record is challenging owing to limited comparative data on extant species. Here, we built forelimb musculoskeletal models of three extant taxa that bracket sprawling-parasagittal postures-tegu lizard, echidna, and opossum-and tested the relationship between three-dimensional joint mobility, muscle action, and posture. Results demonstrate clear functional variation between postural grades, with the parasagittal opossum occupying a distinct region of pose space characterized by a highly retracted and depressed shoulder joint that emphasizes versatility and humeral elevation. Applying our data to the fossil record support trends of an increasingly retracted humerus and greater elevation muscle moment arms indicative of more parasagittal postures throughout synapsid evolution.

Indexed as

BiomechanicsComparative anatomyEvolutionary biologyZoology

Identifiers

PMID37609446
PMCPMC10441569

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.