Evidence map›Paper›PMID 37609350›Full record

ArticlebioRxiv : the preprint server for biology2023

The sterol C-24 methyltransferase encoding gene,

Jinhong Xie, Jeffrey M Rybak, Adela Martin-Vicente, Xabier Guruceaga, Harrison I Thorn, Ashley V Nywening, Wenbo Ge, Josie E Parker, Steven L Kelly, P David Rogers and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jinhong XieGraduate Program in Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.
Jeffrey M RybakDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Adela Martin-VicenteDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN USA.
Xabier GuruceagaDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN USA.
Harrison I ThornGraduate Program in Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.
Ashley V NyweningDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN USA.
Wenbo GeDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN USA.
Josie E ParkerMolecular Biosciences Division, School of Biosciences, Cardiff University, Cardiff, Wales, UK.
Steven L KellyInstitute of Life Science, Swansea University Medical School, Swansea, Wales, UK.
P David RogersDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jarrod R FortwendelDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN USA.
University of Tennessee Health Science Center · USSt. Jude Children's Research Hospital · USCardiff University · GBSwansea University · GB

Funding

Non-cyp51A-mutation Mediated Triazole Resistance in Aspergillus fumigatusR01AI143197 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI FORTWENDEL, JARROD R., ROGERS, P. DAVID · 2020 to 2024
$3.3M
Unlocking the cidal activity of echinocandins against Aspergillus fumigatusR01AI158442 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI FORTWENDEL, JARROD R. · 2021 to 2025
$2.3M
NIAID NIH HHS R01 AI143197NIAID NIH HHS R01 AI158442
6 · The paper itself

Abstract

Ergosterol is a critical component of fungal plasma membranes. Although many currently available antifungal compounds target the ergosterol biosynthesis pathway for antifungal effect, current knowledge regarding ergosterol synthesis remains incomplete for filamentous fungal pathogens like

Identifiers

PMID37609350
PMCPMC10441335
OpenAlexW4385766917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.