Evidence map›Paper›PMID 37609250›Full record

ArticlebioRxiv : the preprint server for biology2023

Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains.

Yajie Gu, Huan Li, Amar Deep, Eray Enustun, Dapeng Zhang, Kevin D Corbett

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yajie GuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA 92093.
Huan LiDepartment of Biology, Saint Louis University, Saint Louis, MO 63103.
Amar DeepDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA 92093.
Eray EnustunDepartment of Molecular Biology, University of California San Diego, La Jolla CA 92093.
Dapeng ZhangDepartment of Biology, Saint Louis University, Saint Louis, MO 63103.
Kevin D CorbettDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA 92093.

Funding

Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunityR35GM144121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett · 2022 to 2026
$2.7M
NIGMS NIH HHS R35 GM144121
6 · The paper itself

Abstract

Prokaryotes encode diverse anti-bacteriophage immune systems, including the single-protein Shedu nuclease. Here we reveal the structural basis for activation of

Indexed as

Antiphage immunityDUF4263PD-(D/E)XK nucleaseTwo-component signalingWhirly domain

Identifiers

PMID37609250
PMCPMC10441436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.