Evidence map›Paper›PMID 37609214›Full record

ArticlebioRxiv : the preprint server for biology2023

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES.

Alessandro Noto, Pasquale Valenzisi, Federica Fratini, Tomasz Kulikowicz, Joshua A Sommers, Flavia Di Feo, Valentina Palermo, Maurizio Semproni, Marco Crescenzi, Robert M Brosh and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Alessandro NotoMechanisms, Biomarkers and Models Section - Genome Stability Group, Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Pasquale ValenzisiMechanisms, Biomarkers and Models Section - Genome Stability Group, Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Federica FratiniCore Facilities Technical-Scientific Service, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Tomasz KulikowiczHelicases and Genomic Integrity Section, Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Baltimore, MD 21224 (USA).
Joshua A SommersHelicases and Genomic Integrity Section, Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Baltimore, MD 21224 (USA).
Flavia Di FeoMechanisms, Biomarkers and Models Section - Genome Stability Group, Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Valentina PalermoMechanisms, Biomarkers and Models Section - Genome Stability Group, Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Maurizio SemproniMechanisms, Biomarkers and Models Section - Genome Stability Group, Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Marco CrescenziCore Facilities Technical-Scientific Service, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Robert M BroshHelicases and Genomic Integrity Section, Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Baltimore, MD 21224 (USA).
Annapaola FranchittoMechanisms, Biomarkers and Models Section - Genome Stability Group, Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Pietro PichierriMechanisms, Biomarkers and Models Section - Genome Stability Group, Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome (Italy).
Istituto Superiore di Sanità · ITNational Institute on Aging · US

Funding

Determining how a Werner helicase (WRN) tumor suppressor complex regulates the human papillomavirus 16 life cycleR01DE029471 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI MORGAN, IAIN · 2021 to 2025
$2.8M
NIDCR NIH HHS R01 DE029471
6 · The paper itself

Abstract

The WRN protein mutated in the hereditary premature aging disorder Werner syndrome plays a vital role in handling, processing, and restoring perturbed replication forks. One of its most abundant partners, Replication Protein A (RPA), has been shown to robustly enhance WRN helicase activity in specific cases when tested

Indexed as

Genome InstabilityRecQ helicasesReplication fork arrestWerner syndrome

Identifiers

PMID37609214
PMCPMC10441285
OpenAlexW4385700895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.