Evidence map›Paper›PMID 37609213›Full record

ArticlebioRxiv : the preprint server for biology2023

Material Properties of Nonpregnant and Pregnant Human Uterine Layers.

Daniella M Fodera, Serena R Russell, Johanna L Lund-Jackson, Shuyang Fang, Xiaowei Chen, Joy-Sarah Y Vink, Michelle L Oyen, Kristin M Myers

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniella M FoderaDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0002-6162-8761
Serena R RussellDepartment of Mechanical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0002-4470-5761
Johanna L Lund-JacksonDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Shuyang FangDepartment of Mechanical Engineering, Columbia University, New York, NY, USA.
Xiaowei ChenDepartment of Pathology, Columbia University Irving Medical Center, New York, NY, USA.
Joy-Sarah Y VinkDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
Michelle L OyenDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-3428-748X
Kristin M MyersDepartment of Mechanical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0002-5989-0242
Columbia University · USColumbia University Irving Medical Center · USWashington University in St. Louis · US

Funding

A Computational Framework for the Clinical Evaluation of the Soft Tissue Mechanics in PregnancyR01HD091153 · NICHD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MYERS, KRISTIN MARIE · 2017 to 2021
$1.6M
NICHD NIH HHS R01 HD091153
6 · The paper itself

Abstract

The uterus has critical biomechanical functions in pregnancy and undergoes dramatic material growth and remodeling from implantation to parturition. The intrinsic material properties of the human uterus and how they evolve in pregnancy are poorly understood. To address this knowledge gap and assess the heterogeneity of these tissues, the time-dependent material properties of all human uterine layers were measured with nanoindentation. The endometrium-decidua layer was found to be the least stiff, most viscous, and least permeable layer of the human uterus in nonpregnant and third-trimester pregnant tissues. In pregnancy, endometrium-decidua becomes stiffer and less viscous with no material property changes observed in the myometrium or perimetrium. Additionally, uterine material properties did not significantly differ between third-trimester pregnant tissues with and without placenta accreta. The foundational data generated by this study will facilitate the development of physiologically accurate models of the human uterus to investigate gynecologic and obstetric disorders.

Indexed as

nanoindentationporo-viscoelasticitypregnancyReproductive biomechanicsuterus

Identifiers

PMID37609213
PMCPMC10441310
OpenAlexW4385667324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.