Evidence map›Paper›PMID 37609200›Full record

ArticlebioRxiv : the preprint server for biology2023

Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature.

Kalev Freeman, Adrian M Sackheim, Amreen Mughal, Masayo Koide, Grace Bonson, Grace Ebner, Grant Hennig, Warren Lockette, Mark T Nelson

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kalev FreemanDepartment of Emergency Medicine, University of Vermont, Burlington, VT, USA.
Adrian M SackheimDepartment of Emergency Medicine, University of Vermont, Burlington, VT, USA.
Amreen MughalDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Masayo KoideDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Grace BonsonDepartment of Emergency Medicine, University of Vermont, Burlington, VT, USA.
Grace EbnerDepartment of Emergency Medicine, University of Vermont, Burlington, VT, USA.
Grant HennigDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Warren LocketteDivision of Endocrinology, Wayne State University School of Medicine, Detroit, MI, USA.
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
University of Vermont · USWayne State University · US

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MARY CUSHMAN, MARK T NELSON · 2020 to 2026
$17.4M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDR01NS119971 · NINDS · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2021 to 2025
$2.6M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Lesions and loss of smooth muscle cells in brain underlies small vessel diseaseRF1NS128963 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JOUTEL, ANNE, NELSON, MARK T · 2022 to 2023
$2.2M
R35 Undergraduate Research SupplementR35GM144099 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kalev Freeman · 2022 to 2026
$2.2M
Functional deficits in neurovascular coupling in Alzheimer's diseaseK99AG075175 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MUGHAL, AMREEN · 2022 to 2023
$282k
NHLBI NIH HHS R35 HL140027NIA NIH HHS K99 AG075175NIGMS NIH HHS P20 GM135007NIGMS NIH HHS R35 GM144099NINDS NIH HHS R01 NS110656NINDS NIH HHS R01 NS119971NINDS NIH HHS RF1 NS128963
6 · The paper itself

Abstract

The accumulation of the microtubule-associated tau protein in and around blood vessels contributes to brain microvascular dysfunction through mechanisms that are incompletely understood. Delivery of nutrients to active neurons in the brain relies on capillary inositol 1,4,5-triphosphate receptor (IP

Indexed as

Alzheimer’sCalciumCerebral Blood FlowDementiaEndothelium

Identifiers

PMID37609200
PMCPMC10441279
OpenAlexW4385781340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.