Evidence map›Paper›PMID 37609153›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection.

Sivaprakasam T Selvavinayagam, Bijulal Aswathy, Yean K Yong, Asha Frederick, Lakshmi Murali, Vasudevan Kalaivani, Karishma S Jith, Manivannan Rajeshkumar, Adukkadukkam Anusree, Meganathan Kannan and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 4 countries.

Sivaprakasam T SelvavinayagamState Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India.
Bijulal AswathyInfection and Inflammation, Department of Biotechnology, Central University of Tamil Nadu, Thiruvarur 610 005, India.
Yean K YongLaboratory Centre, Xiamen University Malaysia, 43 900 Sepang, Selangor, Malaysia.
Asha FrederickNational Tuberculosis Elimination Programme, Chennai, Tamil Nadu, India.
Lakshmi MuraliNational Tuberculosis Elimination Programme, Chennai, Tamil Nadu, India.
Vasudevan KalaivaniState Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India.
Karishma S JithInfection and Inflammation, Department of Biotechnology, Central University of Tamil Nadu, Thiruvarur 610 005, India.
Manivannan RajeshkumarState Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India.
Adukkadukkam AnusreeBlood and Vascular Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610 005, India.
Meganathan KannanBlood and Vascular Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610 005, India.
Natarajan GopalanDepartment of Epidemiology and Public Health, Central University of Tamil Nadu, Thiruvarur 610 005, India.
Ramachandran VigneshPre-clinical Department, Royal College of Medicine, Universiti Kuala Lumpur, Ipoh, Malaysia.
Amudhan MurugesanDepartment of Microbiology, The Government Theni Medical College and Hospital, Theni, India.
Hong Yien TanLaboratory Centre, Xiamen University Malaysia, 43 900 Sepang, Selangor, Malaysia.
Ying ZhangLaboratory Centre, Xiamen University Malaysia, 43 900 Sepang, Selangor, Malaysia.
Samudi ChandramathiDepartment of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.
Munusamy Ponnan SivasankaranSeattle Children's Research Institute, Seattle, WA, USA.
Sakthivel GovindarajDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory Vaccine Center, Atlanta, GA, 30329, USA.
Siddappa N ByrareddyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68131, USA.
Vijayakumar VeluDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory Vaccine Center, Atlanta, GA, 30329, USA.
Marie LarssonDepartment of Biomedicine and Clinical Sciences, Linkoping University, 58 185 Linköping, Sweden.
Esaki M ShankarInfection and Inflammation, Department of Biotechnology, Central University of Tamil Nadu, Thiruvarur 610 005, India.
Sivadoss RajuState Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India.
Central University of Tamil Nadu · INGovernment of Tamil Nadu · INXiamen University Malaysia · MYEmory University · USNational Institute of Research in Tuberculosis · INLinköping University · SEUniversity Malaya Medical Centre · MYUniversity of Kuala Lumpur · MYUniversity of Nebraska Medical Center · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Innate NKT Cells in HIV InfectionR37AI052731 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NIXON, DOUGLAS F · 2007 to 2016
$3.1M
Innate NKT Cells in HIV InfectionR01AI052731 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NIXON, DOUGLAS F · 2002 to 2006
$2.1M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI052731NIAID NIH HHS R37 AI052731NIH HHS P51 OD011132
6 · The paper itself

Abstract

Background: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of Methods: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. We also measured the plasma cytokines using a commercial Results: Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. Conclusions: We postulated that CXCL8 and MCP-1 could be the surrogate biomarkers of LTBI, especially in resource-limited settings.

Indexed as

CytokinesIFN-γIGRAlatent infectionLTBITB elimination

Identifiers

PMID37609153
PMCPMC10441491
OpenAlexW4385762176

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.