Evidence map›Paper›PMID 37609145›Full record

ArticlebioRxiv : the preprint server for biology2023

Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment.

Nathaniel P Skillin, Bruce E Kirkpatrick, Katie M Herbert, Benjamin R Nelson, Grace K Hach, Kemal Arda Günay, Ryan M Khan, Frank W DelRio, Timothy J White, Kristi S Anseth

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nathaniel P SkillinDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Bruce E KirkpatrickDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Katie M HerbertDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Benjamin R NelsonDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Grace K HachDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Kemal Arda GünayDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Ryan M KhanMaterial, Physical, and Chemical Sciences Center, Sandia National Laboratories, Albuquerque, NM, 87185, USA.
Frank W DelRioMaterial, Physical, and Chemical Sciences Center, Sandia National Laboratories, Albuquerque, NM, 87185, USA.
Timothy J WhiteDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
University of Colorado Boulder · USSandia National Laboratories California · US

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Developing near-infrared responsive liquid crystal elastomers for an adjustable pulmonary artery bandF30HL164047 · NHLBI · UNIVERSITY OF COLORADO · PI SKILLIN, NATHANIEL PHILLIP · 2022 to 2025
$172k
NHLBI NIH HHS F30 HL164047NIDCR NIH HHS R01 DE016523
6 · The paper itself

Abstract

In skeletal muscle tissue, injury-related changes in stiffness activate muscle stem cells through mechanosensitive signaling pathways. Functional muscle tissue regeneration also requires the effective coordination of myoblast proliferation, migration, polarization, differentiation, and fusion across multiple length scales. Here, we demonstrate that substrate stiffness anisotropy coordinates contractility-driven collective cellular dynamics resulting in C2C12 myotube alignment over millimeter-scale distances. When cultured on mechanically

Indexed as

collective cell behaviorliquid crystalline polymer networksmechanosensingmyoblastsmyotube alignmentstiffness anisotropy

Identifiers

PMID37609145
PMCPMC10441277
OpenAlexW4385782433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.