Evidence map›Paper›PMID 37609144›Full record

ArticlebioRxiv : the preprint server for biology2023

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection.

Leila B Giron, Qin Liu, Opeyemi S Adeniji, Xiangfan Yin, Toshitha Kannan, Jianyi Ding, David Y Lu, Susan Langan, Jinbing Zhang, Joao L L C Azevedo and 26 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 18 institutions in 1 country.

Leila B GironThe Wistar Institute, Philadelphia, PA, USA.
Qin LiuThe Wistar Institute, Philadelphia, PA, USA.
Opeyemi S AdenijiThe Wistar Institute, Philadelphia, PA, USA.
Xiangfan YinThe Wistar Institute, Philadelphia, PA, USA.
Toshitha KannanThe Wistar Institute, Philadelphia, PA, USA.
Jianyi DingThe Wistar Institute, Philadelphia, PA, USA.
David Y LuThe Wistar Institute, Philadelphia, PA, USA.
Susan LanganJohns Hopkins University, Baltimore, MD, USA.
Jinbing ZhangJohns Hopkins University, Baltimore, MD, USA.
Joao L L C AzevedoThe Wistar Institute, Philadelphia, PA, USA.
Shuk Hang LiUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sergei ShalyginUniversity of Georgia, Athens, Georgia, USA.
Parastoo AzadiUniversity of Georgia, Athens, Georgia, USA.
David B HannaAlbert Einstein College of Medicine, Bronx, NY, USA.
Igho OfotokunDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Jason LazarSUNY Downstate Health Sciences University, New York, NY, USA.
Margaret A FischlUniversity of Miami, Miami, FL, USA.
Sabina HaberlenJohns Hopkins University, Baltimore, MD, USA.
Bernard MacatangayUniversity of Pittsburgh, Pittsburgh, PA, USA.
Adaora A AdimoraUniversity of North Carolina, Chapel Hill, NC, USA.
Beth D JamiesonUniversity of California, Los Angeles, Los Angeles, CA, USA.
Charles RinaldoUniversity of Pittsburgh, Pittsburgh, PA, USA.
Daniel MerensteinGeorgetown University Medical Center, Washington, DC, USA.
Nadia R RoanGladstone Institutes, San Francisco, CA, USA.
Olaf KutschUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Stephen GangeJohns Hopkins University, Baltimore, MD, USA.
Steven WolinskyNorthwestern University, Evanston, IL, USA.
Mallory WittLos Angeles Biomedical Research Institute, Torrance, CA, USA.
Wendy S PostJohns Hopkins University, Baltimore, MD, USA.
Andrew KossenkovThe Wistar Institute, Philadelphia, PA, USA.
Alan LandayRush University, Chicago, IL, USA.
Ian FrankUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Phyllis C TienUniversity of California San Francisco, San Francisco, CA, USA.
Robert GrossUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Todd T BrownJohns Hopkins University, Baltimore, MD, USA.
Mohamed Abdel-MohsenThe Wistar Institute, Philadelphia, PA, USA.
The Wistar Institute · USJohns Hopkins University · USUniversity of Georgia · USUniversity of Pennsylvania · USUniversity of Pittsburgh · USAlbert Einstein College of Medicine · USEmory University · USGeorgetown University · USGladstone Institutes · USNorthwestern University · USRush University · USSUNY Downstate Health Sciences University · USThe Lundquist Institute · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Savita Pahwa · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NCI NIH HHS R50 CA211199NHLBI NIH HHS R01 HL095129NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI045008NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS R01 AI165079NIAID NIH HHS R21 AI170166NIA NIH HHS R01 AG062383NIDDK NIH HHS R01 DK123733NIGMS NIH HHS R24 GM137782NIMH NIH HHS P30 MH116867NINDS NIH HHS R01 NS117458
6 · The paper itself

Abstract

People with HIV (PWH) experience an increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors that contribute to or are associated with this vulnerability remain uncertain. In the general population, alterations in the glycomes of circulating IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG glycomes of cross-sectional and longitudinal samples from 1,216 women and men, both living with virally suppressed HIV and those without HIV. Our glycan-based machine learning models indicate that living with chronic HIV significantly accelerates the accumulation of pro-aging-associated glycomic alterations. Consistently, PWH exhibit heightened expression of senescence-associated glycan-degrading enzymes compared to their controls. These glycomic alterations correlate with elevated markers of inflammatory aging and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit reduced anti-HIV IgG-mediated innate immune functions. These findings hold significant potential for the development of glycomic-based biomarkers and tools to identify and prevent premature aging and comorbidities in people living with chronic viral infections.

Indexed as

ADCCADCDADCPAgingBiological ageCancerGlycomeHIVIgGInflammationSubclinical atherosclerosis

Identifiers

PMID37609144
PMCPMC10441429
OpenAlexW4385765887

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.