Evidence map›Paper›PMID 37609137›Full record

ArticlebioRxiv : the preprint server for biology2023

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability.

Richard Drexler, Robin Khatri, Thomas Sauvigny, Malte Mohme, Cecile L Maire, Alice Ryba, Yahya Zghaibeh, Lasse Dührsen, Amanda Salviano-Silva, Katrin Lamszus and 32 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 13 institutions in 3 countries.

Richard DrexlerDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Robin KhatriInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thomas SauvignyDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Malte MohmeDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Cecile L MaireDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Alice RybaDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Yahya ZghaibehDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lasse DührsenDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Amanda Salviano-SilvaDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Katrin LamszusDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Manfred WestphalDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jens GemptDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Annika K WefersInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Julia NeumannInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Helena BodeResearch Institute Children's Cancer Center Hamburg, Hamburg, Germany.
Fabian HausmannInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tobias B HuberIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefan BonnInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kerstin JüttenDepartment of Neurosurgery, University Hospital Aachen, Aachen, Germany.
Daniel DelevDepartment of Neurosurgery, University Hospital Aachen, Aachen, Germany.
Katharina J WeberNeurological Institute (Edinger Institute), University Hospital Frankfurt, Frankfurt am Main, Germany.
Patrick N HarterNeurological Institute (Edinger Institute), University Hospital Frankfurt, Frankfurt am Main, Germany.
Julia OnkenDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Peter VajkoczyDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
David CapperDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Benedikt WiestlerDepartment of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University Munich, Munich.
Michael WellerDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zurich, Switzerland. Department of Neurology, University of Zürich, Switzerland.
Berend SnijderInstitute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Alicia BuckDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zurich, Switzerland. Department of Neurology, University of Zürich, Switzerland.
Tobias WeissDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zurich, Switzerland. Department of Neurology, University of Zürich, Switzerland.
Michael B KeoughDepartment of Neurology, Stanford University, Stanford, CA, 94305, USA.
Lijun NiDepartment of Neurology, Stanford University, Stanford, CA, 94305, USA.
Michelle MonjeDepartment of Neurology, Stanford University, Stanford, CA, 94305, USA.
Dana SilverbushBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Volker HovestadtBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Mario L SuvàBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Saritha KrishnaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA.
Shawn L Hervey-JumperDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA.
Ulrich SchüllerInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Dieter H HeilandDepartment of Neurosurgery, Medical Center University of Freiburg, Freiburg, Germany.
Sonja HänzelmannInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Franz L RicklefsDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Universität Hamburg · DEBroad Institute · USStanford University · USUniversity Hospital of Zurich · CHCharité - Universitätsmedizin Berlin · DEGoethe University Frankfurt · DEUniversitätsklinikum Aachen · DEUniversity of California, San Francisco · USETH Zurich · CHHumboldt-Universität zu Berlin · DEKinderkrebs-Zentrum Hamburg · DETUM Klinikum · DEUniversity of Freiburg · DE

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Tracy T Batchelor · 2013 to 2026
$33.5M
Targeting the neuronal microenvironment in glioblastomaU19CA264504 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Michelle Monje-Deisseroth · 2021 to 2026
$6.4M
Glioma Circuitry: Bridging Systems Neuroscience and CancerDP1NS111132 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2018 to 2022
$5.7M
Neuronal Regulation of Low-Grade GliomagenesisR01CA258384 · NCI · STANFORD UNIVERSITY · PI David H Gutmann, Michelle Monje-Deisseroth · 2022 to 2026
$3.1M
Neuronal activity-regulated mechanisms of glioma growthR01NS092597 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2016 to 2021
$2.1M
Intratumoral functional connectivity with implications on synaptogenesis and aphasia recovery in adult astrocytic WHO II-III gliomaK08NS110919 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERVEY-JUMPER, SHAWN L. · 2019 to 2023
$1.0M
A deep-transfer-learning framework to transfer clinical information to single cells and spatial locations in cancer tissuesR21CA264339 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI JOHNSON, TRAVIS STEELE, ZHANG, JIE · 2022 to 2023
$394k
NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA165962NCI NIH HHS R01 CA258384NCI NIH HHS R21 CA264339NCI NIH HHS U19 CA264504NINDS NIH HHS DP1 NS111132NINDS NIH HHS K08 NS110919NINDS NIH HHS R01 NS092597
6 · The paper itself

Abstract

Neural-tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is nascent. We present an epigenetically defined neural signature of glioblastoma that independently affects patients' survival. We use reference signatures of neural cells to deconvolve tumor DNA and classify samples into low- or high-neural tumors. High-neural glioblastomas exhibit hypomethylated CpG sites and upregulation of genes associated with synaptic integration. Single-cell transcriptomic analysis reveals high abundance of stem cell-like malignant cells classified as oligodendrocyte precursor and neural precursor cell-like in high-neural glioblastoma. High-neural glioblastoma cells engender neuron-to-glioma synapse formation

Indexed as

BDNFcancer neuroscienceconnectivityDIPGDMGGBMGliomaneuronneuronal activityNPCOPCstem cellsynapse

Identifiers

PMID37609137
PMCPMC10441357
OpenAlexW4385638586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.