Evidence map›Paper›PMID 37609130›Full record

ArticlebioRxiv : the preprint server for biology2023

A genome-wide atlas of human cell morphology.

Meraj Ramezani, Julia Bauman, Avtar Singh, Erin Weisbart, John Yong, Maria Lozada, Gregory P Way, Sanam L Kavari, Celeste Diaz, Marzieh Haghighi and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 27 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Meraj RamezaniBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Julia BaumanBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Avtar SinghBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Erin WeisbartBroad Institute of MIT & Harvard, Cambridge, MA, USA.
John YongCalico Life Sciences LLC, South San Francisco, CA, USA.
Maria LozadaBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Gregory P WayBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Sanam L KavariBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Celeste DiazBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Marzieh HaghighiBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Thiago M BatistaType 2 Diabetes Systems Genomics Initiative of the Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Joaquín Pérez-SchindlerType 2 Diabetes Systems Genomics Initiative of the Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Melina ClaussnitzerType 2 Diabetes Systems Genomics Initiative of the Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Shantanu SinghBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Beth A CiminiBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Paul C BlaineyBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Anne E CarpenterBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Calvin H JanCalico Life Sciences LLC, South San Francisco, CA, USA.
James T NealBroad Institute of MIT & Harvard, Cambridge, MA, USA.
Broad Institute · US

Funding

Optical Functional GenomicsDP2GM146252 · NIGMS · BROAD INSTITUTE, INC. · PI NEAL, JAMES THOMAS · 2021 to 2024
$2.4M
NIGMS NIH HHS DP2 GM146252
6 · The paper itself

Abstract

A key challenge of the modern genomics era is developing data-driven representations of gene function. Here, we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing three genome-scale genotype-phenotype maps comprising >20,000 single-gene CRISPR-Cas9-based knockout experiments in >30 million cells. Our optical pooled cell profiling approach (PERISCOPE) combines a de-stainable high-dimensional phenotyping panel (based on Cell Painting

Identifiers

PMID37609130
PMCPMC10441312
OpenAlexW4385635075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.