ReviewEClinicalMedicine2023
Guideline for the management of fatigue in children and adolescents with cancer or pediatric hematopoietic cell transplant recipients: 2023 update.
Review in EClinicalMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exercise intervention for children with acute leukemia: a best evidence summary.Frontiers in pediatrics · 2026Pooled it
- Prevalence and Factors Associated With Cancer-Related Fatigue Among Children and Adolescents Undergoing Cancer Treatment: A Systematic Review and Meta-Analysis.Cancer medicine · 2024Pooled it
- Individualized online exercise therapy aids recovery in pediatric long-COVID-findings from an exploratory randomized controlled trial.European journal of pediatrics · 2026Trial
- Trial
- Article
- Case Series: Can Daily Patient-Reported Outcome Measures Be Implemented for Cancer-Related Fatigue?Cancer reports (Hoboken, N.J.) · 2026Article
- Cancer-related fatigue in children during treatment: a 5-year cohort study of daily patient-reported outcomes with clinical implications.EClinicalMedicine · 2025Article
- Integrative and Complementary Interventions Result in Significant Positive Effect Sizes in Quality of Life and Symptom Burden among Patients with Pediatric Cancer and Other Serious Illness.Research square · 2025Article
- Article
- Quality of life, fatigue, depression, attention deficits, and pain after childhood Langerhans cell histiocytosis.Blood neoplasia · 2025Article
- Management of fatigue in children with cancer: a survey of pediatric hematology-oncology professionals' knowledge, attitudes, and practices in the United States and Canada.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Utilizing complementary therapy to enhance quality of life and reduce stress and fatigue in pediatric cancer patients.World journal of clinical cases · 2025Review
- Biopsychosocial risk factors for pain in early phases of pediatric cancer treatment.Frontiers in psychology · 2025Article
- Severely reduced physical performance is already present at the time of admission for stem cell transplantation.BMJ open sport & exercise medicine · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective was to update a clinical practice guideline (CPG) for the management of fatigue in children and adolescents with cancer or pediatric hematopoietic cell transplant recipients. We reconvened a multi-disciplinary and multi-national panel. While the previous 2018 CPG evaluated adult and pediatric randomized controlled trials (RCTs) to manage fatigue, this 2023 update revised previous recommendations based only on pediatric RCTs. Twenty RCTs were included in the updated systematic review. Physical activity significantly reduced fatigue (standardized mean difference -0.44, 95% confidence interval -0.64 to -0.24; n = 8 RCTs). Using the 2018 recommendations as a basis, the panel continued to make strong recommendations to use physical activity, and to offer relaxation, mindfulness or both, to manage fatigue in pediatric patients. Cognitive or cognitive behavioral therapies may be offered. Pharmacological approaches should not be routinely used. The panel made a new good practice statement to routinely assess for fatigue, ideally using a validated scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.