The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus.

Xiangting Li, Sara Habibipour, Tom Chou, Otto O Yang

Open access · goldAbstract readPreprint

In one paragraph

Article in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

1.6field-weighted citation impact, top 13% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Updated by
The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus.2023

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiangting LiDepartment of Computational Medicine, UCLA, Los Angeles, CA, United States.

Sara HabibipourDepts. of Medicine and Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA, United States.

Tom ChouDepartment of Computational Medicine, UCLA, Los Angeles, CA, United States.

Otto O YangDepts. of Medicine and Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA, United States.

University of California, Los Angeles · US

Funding

Tracking clonal dynamics during hematopoiesis: mechanistic insight via modeling and data analysisR01HL146552 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHOU, TOM · 2019 to 2022

$907k

NHLBI NIH HHS R01 HL146552

6 · The paper itself

Abstract

Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier. It is unclear whether these single nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible (GTR) model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events.

Identifiers

PMID37608930

PMCPMC10441442

OpenAlexW4385682151

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.