ArticleJournal of pathology and translational medicine2023
Diagnostic proficiency test using digital cytopathology and comparative assessment of whole slide images of cytologic samples for quality assurance program in Korea.
Article in Journal of pathology and translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Diagnostic concordance of remote WSI-based thyroid cytology compared to conventional cytological diagnosis: a pilot study.Diagnostic pathology · 2026Article
- Practice of Cytopathology in Korea: A 40-Year Evolution Through Standardization, Digital Transformation, and Global Partnership.Diagnostic cytopathology · 2026Review
- Integration of Digital Cytology in Quality Assurance Programs for Cytopathology.Acta cytologica · 2026Review
- Quantitative Assessment of Focus Quality in Whole-Slide Imaging of Thyroid Liquid-Based Cytology Using Laplacian Variance.Endocrine pathology · 2025Article
- National quality assurance program using digital cytopathology: a 5-year digital transformation experience by the Korean Society for Cytopathology.Journal of pathology and translational medicine · 2025Article
- Sensitivity, Specificity, and Cost-Benefit Effect Between Primary Human Papillomavirus Testing, Primary Liquid-Based Cytology, and Co-Testing Algorithms for Cervical Lesions.Diagnostic cytopathology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe Korean Society for Cytopathology introduced a digital proficiency test (PT) in 2021. However, many doubtful opinions remain on whether digitally scanned images can satisfactorily present subtle differences in the nuclear features and chromatin patterns of cytological samples.
methodsWe prepared 30 whole-slide images (WSIs) from the conventional PT archive by a selection process for digital PT. Digital and conventional PT were performed in parallel for volunteer institutes, and the results were compared using feedback. To assess the quality of cytological assessment WSIs, 12 slides were collected and scanned using five different scanners, with four cytopathologists evaluating image quality through a questionnaire.
resultsAmong the 215 institutes, 108 and 107 participated in glass and digital PT, respectively. No significant difference was noted in category C (major discordance), although the number of discordant cases was slightly higher in the digital PT group. Leica, 3DHistech Pannoramic 250 Flash, and Hamamatsu NanoZoomer 360 systems showed comparable results in terms of image quality, feature presentation, and error rates for most cytological samples. Overall satisfaction was observed with the general convenience and image quality of digital PT.
conclusionsAs three-dimensional clusters are common and nuclear/chromatin features are critical for cytological interpretation, careful selection of scanners and optimal conditions are mandatory for the successful establishment of digital quality assurance programs in cytology.
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Registered trials
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