Observational studyLipids in health and disease2023
The association between triglyceride glucose index and arthritis: a population-based study.
Observational study in Lipids in health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- E-selectin, but not CRP, partially mediates the association between metabolic indices and insulin resistance in older adults: a mediation analysis.Asian biomedicine : research, reviews and news · 2026Article
- Association between the C-reactive protein-triglyceride-glucose index and incident cardiovascular disease in middle-aged and older adults with arthritis: a nationwide prospective cohort study with hospital-based cross-sectional replication.Frontiers in immunology · 2026Article
- Association of Triglyceride-to-HDL Cholesterol Ratio with Osteoarthritis: Multicenter Evidence and Application of an Interactive Risk Visualization Tool.Journal of inflammation research · 2026Article
- Association between triglyceride glucose index and deep vein thrombosis following total knee arthroplasty: a retrospective case-control study.BMC geriatrics · 2025Article
- Association between erectile dysfunction and relative fat mass in adult men in the United States.Translational andrology and urology · 2025Article
- Association between Osteoarthritis and the Triglyceride-Glucose Index in the Korean Population: A Large-Scale Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Association of eight anthropometric indexes related to obesity with the prevalence of clinical osteoarthritis among American adults: a national cross-sectional study.European journal of medical research · 2025Article
- TyG Index and Related Indices Predicting Hypertension: Mediation by Neutrophil-to-Lymphocyte Ratio in Multiple Chinese Cohorts.Nutrients · 2025Article
- The association between the American heart association's new "Life's Essential 8" and different types of arthritis: insights from a large population study.Scientific reports · 2025Observational
- Association between triglyceride-glucose index and thyroid nodule: a cross-sectional study in Western Liaoning Province, China.Scientific reports · 2025Article
- Association between triglyceride glucose index and organ involvement in patients with systemic sclerosis.Scientific reports · 2025Article
- A nutrient wide association study of cardiovascular disease prevalence in older adults from NHANES 2007 to 2018.Scientific reports · 2025Article
- Association between lipid accumulation products and relative handgrip strength: a large population-based study.Scientific reports · 2025Article
- Association between triglyceride levels and rheumatoid arthritis prevalence in women: a cross-sectional study of NHANES (1999-2018).BMC women's health · 2025Article
- Exploring the TyG Index and the Homeostasis Model Assessment of Insulin Resistance as Insulin Resistance Markers: Implications for Fibromyalgia Management and Understanding-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Association Between Triglyceride-Glucose Related Index and Endometriosis Varies According to Educational Level.Nutrients · 2025Article
- Interplay between BMI, neutrophil, triglyceride and uric acid: a case-control study and bidirectional multivariate mendelian randomization analysis.Nutrition & metabolism · 2025Article
- Association between insulin resistance-related lipid indices and arthritis: a U. S. cross-sectional study.Frontiers in nutrition · 2025Article
- Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database.Frontiers in immunology · 2025Article
- Association between triglyceride glucose-waist height ratio index and overactive bladder: based on NHANES 2005-2018.Frontiers in endocrinology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
objectivesInsulin resistance is a well-established contributor to inflammation; however, the specific association between the triglyceride glucose (TyG) index, a biomarker reflecting insulin resistance, and arthritis remains unexplored. As a result, the main aim of this study was to examine the correlation between the TyG index and arthritis.
methodsThis observational study used data from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 2007 and 2018. To investigate the relationship between the TyG index and arthritis, various statistical analyses were employed, including weighted multivariable logistic regression analysis, subgroup analysis, curve fit analysis, and threshold effect analysis.
resultsIn total, 14,817 patients were enrolled in the trial, with 4,191 individuals (28.29%) diagnosed with arthritis. An increased risk of arthritis was found to be significantly correlated with higher TyG index values (odds ratio OR = 1.15, 95% confidence interval CI: 1.07-1.23), according to the results of multivariable logistic regression analysis after full adjustment. Subgroup analysis and interaction tests further indicated that the TyG index exhibited an additive effect when combined with other established risk factors, including age (OR = 1.29; 95% CI: 1.17-1.41), body mass index (BMI) (OR = 1.43; 95% CI: 1.24-1.69), and diabetes (OR = 1.20; 95% CI: 1.11-1.31). Additionally, curve fit analysis and threshold effect analysis demonstrated a nonlinear relationship with a breakpoint identified at 8.08 µmol/L.
conclusionThe TyG index was positively correlated with arthritis in adults under 60 years of age in the United States who had normal weight and no diabetes. Further large-scale prospective studies are warranted for a comprehensive analysis of the role of the TyG index in arthritis.
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