SynthesisBMC infectious diseases2023
Prevalence and trends of advanced HIV disease among antiretroviral therapy-naïve and antiretroviral therapy-experienced patients in South Africa between 2010-2021: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Factors influencing the survival of patients with advanced HIV disease in Guinea from 2015 to 2024.BMC public health · 2026Article
- Beyond the Diagnosis: Exploring Illness Identity in HIV and Its Impact on Health Outcomes.AIDS and behavior · 2026Article
- Descriptive epidemiology of opportunistic infections among patients with advanced HIV disease in Kinshasa, Democratic Republic of Congo.BMC infectious diseases · 2026Article
- Burden and predictors of advanced HIV disease among people living with HIV at Zewditu Memorial Hospital in Addis Ababa, Ethiopia.Frontiers in public health · 2026Article
- Closing the "Missing Middle" in Advanced HIV Disease Care for Adolescents in Sub-Saharan Africa: Early Identification, Integrated Care, and Continuity After Discharge.HIV/AIDS (Auckland, N.Z.) · 2026Article
- Decreasing Adult Prevalence of Advanced HIV Disease From 2 Population-Based HIV Impact Assessments in Eswatini, Lesotho, Malawi, Tanzania, Uganda, Zambia, and Zimbabwe, 2015-2023.Open forum infectious diseases · 2026Article
- Article
- Quality assessment of data for decentralised antiretroviral therapy referrals and laboratory results in the South African national electronic HIV management register TIER.Net.PLOS global public health · 2026Article
- Differences in Mortality Between Treatment-Naive and Treatment-Discontinuing Hospitalized Individuals With Advanced HIV Disease: A Comparative Retrospective Study From Mexico City.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Dolutegravir rollout for treatment of HIV with a focus on advanced disease and tuberculosis coinfection: findings from rural KwaZulu-Natal, South Africa (2019-2023).AIDS research and therapy · 2025Article
- Dolutegravir Resistance in Mozambique: Insights from a Programmatic HIV Resistance Testing Intervention in a Highly Antiretroviral Therapy-Experienced Cohort.Infectious disease reports · 2025Article
- Article
- Factors associated with mortality among people with advanced HIV disease in rural uganda: a retrospective study.BMC infectious diseases · 2025Article
- "If your CD4 count lowers, that is when you are similar to a person that is non-existent" A qualitative exploration of perceptions around advanced HIV disease in South Africa.BMC public health · 2025Article
- Treatment of Advanced HIV in the Modern Era.Drugs · 2025Review
- Trends in population HIV viral suppression: a longitudinal analysis.AIDS (London, England) · 2025Article
- Trends in prevalent TB among persons enrolling for HIV care before and after 'Test and Treat' across East-Africa.IJTLD open · 2025Article
- Host-Directed Therapies Based on Protease Inhibitors to ControlMicroorganisms · 2025Review
- Impact of increasing CD4 count threshold eligibility for antiretroviral therapy initiation on advanced HIV disease and tuberculosis prevalence and incidence in South Africa: an interrupted time series analysis.BMJ global health · 2025Article
- Association between cytokine and increased risk of death in ART- naïve and ART-non-adherence patients hospitalized with advanced HIV disease.BMC infectious diseases · 2025Observational
Corrections and comments
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Authors and funding
5 authors.
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Abstract
backgroundDespite the significant progress made in South Africa in getting millions of individuals living with HIV into care, many patients still present or re-enter care with Advanced HIV Disease (AHD). We aimed to estimate the prevalence of AHD among ART-naive and ART-experienced patients in South Africa using studies published between January 2010 and May 2022.
methodsWe searched for relevant data on PubMed, CINAHL, Scopus and other sources, with a geographical filters limited to South Africa, up to May 31, 2022. Two reviewers conducted all screening, eligibility assessment, data extraction, and critical appraisal. We synthesized the data using the inverse-variance heterogeneity model and Freeman-Tukey transformation. We assessed heterogeneity using the I
resultsWe identified 2,496 records, of which 53 met the eligibility criteria, involving 11,545,460 individuals. The pooled prevalence of AHD among ART-naive and ART-experienced patients was 43.45% (95% CI 40.1-46.8%, n = 53 studies) and 58.6% (95% CI 55.7 to 61.5%, n = 2) respectively. The time trend analysis showed a decline of 2% in the prevalence of AHD among ART-naive patients per year. However, given the high heterogeneity between studies, the pooled prevalence should be interpreted with caution.
conclusionDespite HIV's evolution to a chronic disease, our findings show that the burden of AHD remains high among both ART-naive and ART-experienced patients in South Africa. This emphasizes the importance of regular measurement of CD4 cell count as an essential component of HIV care. In addition, providing innovative adherence support and interventions to retain ART patients in effective care is a crucial priority for those on ART.
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