Evidence map›Paper›PMID 37608290›Full record

ArticleBMC complementary medicine and therapies2023

Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta

Ridho Islamie, Su Lwin Lwin Myint, Tissana Rojanaratha, Garnpimol Ritthidej, Oraphan Wanakhachornkrai, Onsurang Wattanathamsan, Ratchanee Rodsiri

Open access · goldAbstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  17. Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice.Advances in pharmacological and pharmaceutical sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ridho IslamieDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Su Lwin Lwin MyintDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Tissana RojanarathaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Garnpimol RitthidejDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Oraphan WanakhachornkraiPhysiology Unit, Department of Medical Sciences, Faculty of Sciences, Rangsit University, Pathumthani, 12000, Thailand.
Onsurang WattanathamsanDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Ratchanee RodsiriDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. ratchanee.r@pharm.chula.ac.th.
Chulalongkorn University · THRangsit University · THThai Red Cross Society · TH

Funding

Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University RCU_H_64_027_33
6 · The paper itself

Abstract

backgroundAmyloid-β

methodsMemory impairment was induced via direct intracerebroventricular injection of Aβ

resultsThe intranasal administration of AA in SLNs attenuated learning and memory impairment induced by Aβ

conclusionsThese results suggested that nose-to-brain delivery of AA in SLNs could be a promising strategy to treat the early stage of AD.

Indexed as

Alzheimer DiseaseNeuroprotective AgentsAmyloid beta-PeptidesAnimalsBrainLiposomesMiceNanoparticlesPentacyclic TriterpenesAmyloid beta-Peptidesasiatic acidLipid NanoparticlesLiposomesNeuroprotective AgentsPentacyclic TriterpenesAmyloid betaAsiatic acidMemory dysfunctionMiceNose-to-brainSLNs

Identifiers

PMID37608290
PMCPMC10464452
OpenAlexW4386068576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.