Evidence map›Paper›PMID 37607940›Full record

ArticleNature communications2023

Structural insights into opposing actions of neurosteroids on GABA

Dagimhiwat H Legesse, Chen Fan, Jinfeng Teng, Yuxuan Zhuang, Rebecca J Howard, Colleen M Noviello, Erik Lindahl, Ryan E Hibbs

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. A Non-Classical Neuroactive Steroid Exhibiting Potent, Efficacious GABAbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
  19. Article
  20. Experimental and Computational Investigation of the Target and Mechanisms ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dagimhiwat H LegesseDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.
Chen FanDept. of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.ORCID http://orcid.org/0000-0003-1211-3427
Jinfeng TengDepartment of Neurobiology, University of California San Diego, La Jolla, CA, USA.
Yuxuan ZhuangDept. of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.ORCID http://orcid.org/0000-0003-4390-8556
Rebecca J HowardDept. of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.ORCID http://orcid.org/0000-0003-2049-3378
Colleen M NovielloDepartment of Neurobiology, University of California San Diego, La Jolla, CA, USA.
Erik LindahlDept. of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden. erik.lindahl@scilifelab.se.ORCID http://orcid.org/0000-0002-2734-2794
Ryan E HibbsDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA. rehibbs@ucsd.edu.ORCID http://orcid.org/0000-0003-4283-1147

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Structure and Function of GABA-A ReceptorsR01DA047325 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI Ryan E Hibbs, David W Nauen · 2019 to 2026
$4.4M
Structure and mechanism of extrasynaptic GABAA receptorsF31DA051176 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI LEGESSE, DAGIMHIWAT · 2020 to 2022
$103k
NIDA NIH HHS F31 DA051176NIDA NIH HHS R01 DA047325NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

γ-Aminobutyric acid type A (GABA

Indexed as

NeurosteroidsBinding SitesFemalegamma-Aminobutyric AcidHumansPregnanoloneReceptors, GABA-ASulfatesgamma-Aminobutyric AcidNeurosteroidsPregnanoloneReceptors, GABA-ASulfates

Identifiers

PMID37607940
PMCPMC10444788

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.