ArticleDevelopmental psychobiology2023
Early adversity changes the economic conditions of mouse structural brain network organization.
Article in Developmental psychobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Poverty and caregiver mental health are related to infant and toddler resting-state brain networks: insights from fNIRS.Neurophotonics · 2026Article
- Article
- Volatility-driven learning in human infants.Science advances · 2025Article
- Premature birth changes wiring constraints in neonatal structural brain networks.Nature communications · 2025Article
- Brain wiring economics, network organisation and population-level genomics.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dimensions of early life adversity and their associations with functional brain organisation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The adaptive stochasticity hypothesis: Modeling equifinality, multifinality, and adaptation to adversity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Early adversity changes the economic conditions of mouse structural brain network organization.Developmental psychobiology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Early adversity can change educational, cognitive, and mental health outcomes. However, the neural processes through which early adversity exerts these effects remain largely unknown. We used generative network modeling of the mouse connectome to test whether unpredictable postnatal stress shifts the constraints that govern the organization of the structural connectome. A model that trades off the wiring cost of long-distance connections with topological homophily (i.e., links between regions with shared neighbors) generated simulations that successfully replicate the rodent connectome. The imposition of early life adversity shifted the best-performing parameter combinations toward zero, heightening the stochastic nature of the generative process. Put simply, unpredictable postnatal stress changes the economic constraints that reproduce rodent connectome organization, introducing greater randomness into the development of the simulations. While this change may constrain the development of cognitive abilities, it could also reflect an adaptive mechanism that facilitates effective responses to future challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.