Evidence map›Paper›PMID 37607825›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Decreased GABA+ ratios referenced to creatine and phosphocreatine in the left dorsolateral prefrontal cortex of females of reproductive age with major depression.

Kim H Tran, Jessica Luki, Sarah Hanstock, Christopher C Hanstock, Peter Seres, Katherine Aitchison, Jean-Michel Le Melledo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Effects of GABA, Sex, and Stress on Reward Learning in Current and Remitted Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kim H TranFrom the Department of Psychiatry, University of Alberta, Edmonton, Alta. (Tran, Luki, S. Hanstock, Aitchison, Le Melledo); the Department of Biomedical Engineering, University of Alberta, Edmonton, Alta. (C. Hanstock, Seres); the Department of Medical Genetics, University of Alberta, Edmonton, Alta. (Aitchison); the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Women and Children's Research Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Psychiatry Section, Division of Clinical Sciences, Northern Ontario School of Medicine, Thunder Bay, Ont. (Aitchison).
Jessica LukiFrom the Department of Psychiatry, University of Alberta, Edmonton, Alta. (Tran, Luki, S. Hanstock, Aitchison, Le Melledo); the Department of Biomedical Engineering, University of Alberta, Edmonton, Alta. (C. Hanstock, Seres); the Department of Medical Genetics, University of Alberta, Edmonton, Alta. (Aitchison); the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Women and Children's Research Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Psychiatry Section, Division of Clinical Sciences, Northern Ontario School of Medicine, Thunder Bay, Ont. (Aitchison).
Sarah HanstockFrom the Department of Psychiatry, University of Alberta, Edmonton, Alta. (Tran, Luki, S. Hanstock, Aitchison, Le Melledo); the Department of Biomedical Engineering, University of Alberta, Edmonton, Alta. (C. Hanstock, Seres); the Department of Medical Genetics, University of Alberta, Edmonton, Alta. (Aitchison); the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Women and Children's Research Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Psychiatry Section, Division of Clinical Sciences, Northern Ontario School of Medicine, Thunder Bay, Ont. (Aitchison).
Christopher C HanstockFrom the Department of Psychiatry, University of Alberta, Edmonton, Alta. (Tran, Luki, S. Hanstock, Aitchison, Le Melledo); the Department of Biomedical Engineering, University of Alberta, Edmonton, Alta. (C. Hanstock, Seres); the Department of Medical Genetics, University of Alberta, Edmonton, Alta. (Aitchison); the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Women and Children's Research Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Psychiatry Section, Division of Clinical Sciences, Northern Ontario School of Medicine, Thunder Bay, Ont. (Aitchison).
Peter SeresFrom the Department of Psychiatry, University of Alberta, Edmonton, Alta. (Tran, Luki, S. Hanstock, Aitchison, Le Melledo); the Department of Biomedical Engineering, University of Alberta, Edmonton, Alta. (C. Hanstock, Seres); the Department of Medical Genetics, University of Alberta, Edmonton, Alta. (Aitchison); the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Women and Children's Research Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Psychiatry Section, Division of Clinical Sciences, Northern Ontario School of Medicine, Thunder Bay, Ont. (Aitchison).
Katherine AitchisonFrom the Department of Psychiatry, University of Alberta, Edmonton, Alta. (Tran, Luki, S. Hanstock, Aitchison, Le Melledo); the Department of Biomedical Engineering, University of Alberta, Edmonton, Alta. (C. Hanstock, Seres); the Department of Medical Genetics, University of Alberta, Edmonton, Alta. (Aitchison); the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Women and Children's Research Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Psychiatry Section, Division of Clinical Sciences, Northern Ontario School of Medicine, Thunder Bay, Ont. (Aitchison).
Jean-Michel Le MelledoFrom the Department of Psychiatry, University of Alberta, Edmonton, Alta. (Tran, Luki, S. Hanstock, Aitchison, Le Melledo); the Department of Biomedical Engineering, University of Alberta, Edmonton, Alta. (C. Hanstock, Seres); the Department of Medical Genetics, University of Alberta, Edmonton, Alta. (Aitchison); the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Women and Children's Research Institute, University of Alberta, Edmonton, Alta. (Aitchison); the Psychiatry Section, Division of Clinical Sciences, Northern Ontario School of Medicine, Thunder Bay, Ont. (Aitchison) jmlemelledo@gmail.com.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been suggested that the dorsolateral prefrontal cortex (DLPFC), especially the left DLPFC, has an important role in the pathophysiology and the treatment of major depressive disorder (MDD); furthermore, the contributory and antidepressant role of γ-aminobutyric acid (GABA) is increasingly recognized. Given that most female patients with MDD are of reproductive age, we sought to assess in vivo baseline GABA levels in the left DLPFC among unmedicated females of reproductive age with depression.

methodsWe compared healthy females and females with MDD. Both groups were of reproductive age. We confirmed absence of current or past psychiatric diagnosis among healthy controls or a current diagnosis of MDD via a structured interview. We measured GABA+ (including homocarnosine and macromolecules), referenced to creatine and phosphocreatine, via magnetic resonance spectroscopy using a 3 Tesla magnet.

resultsWe included 20 healthy controls and 13 participants with MDD. All participants were unmedicated at the time of the study. All females were scanned during the early follicular phase of the menstrual cycle. Levels of GABA+ in the left DLPFC were significantly lower among participants with MDD (median 0.08) than healthy controls (median 0.10; LIMITATIONS: When we adjusted for fit error as a covariate, we lost statistical significance for left DLPFC GABA+. However, when we adjusted for signal-to-noise ratio, statistical significance was maintained.

conclusionOur results suggest that GABA+ levels in the left DLPFC may vary by depression status and should be examined as a possible treatment target.

Indexed as

CreatineMajor Depressive DisorderDepressionDorsolateral Prefrontal CortexFemaleHumansPhosphocreatineCreatinePhosphocreatine

Identifiers

PMID37607825
PMCPMC10446145
OpenAlexW4386057351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.