ArticleBMJ open2023
Prognostic value of blood urea nitrogen to serum albumin ratio for acute kidney injury and in-hospital mortality in intensive care unit patients with intracerebral haemorrhage: a retrospective cohort study using the MIMIC-IV database.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 18 citations in OpenAlex.
- Blood urea nitrogen to serum albumin ratio, systemic inflammation response index and diabetic macrovascular complications in Chinese inpatients: a cross-sectional analysis.Journal of health, population, and nutrition · 2026Article
- A nomogram model for predicting acute kidney injury in critically ill patients with upper gastrointestinal bleeding: a study based on the MIMIC-IV database and external validation.BMC gastroenterology · 2026Article
- Association between blood urea nitrogen-to-albumin ratio and postoperative acute kidney injury in patients undergoing off-pump coronary artery bypass grafting: a retrospective observational study.BMC cardiovascular disorders · 2026Observational
- Association between the blood urea nitrogen to albumin ratio and 30-day mortality in critically ill children with acute kidney injury.Scientific reports · 2026Article
- The association between blood urea nitrogen to serum albumin ratio and all-cause mortality in critically ill patients with atrial fibrillation.European journal of medical research · 2026Article
- Predictive Value of the Lowest Serum Albumin Level During Hospitalization in Patients With Intracerebral Hemorrhage.Neurology research international · 2026Article
- LDAR is superior to other albumin-derived indices in predicting 28-day ICU mortality in critically ill patients with intracerebral hemorrhage: a two-cohort study.Frontiers in nutrition · 2026Article
- Preoperative serum Raman spectroscopy and machine learning for predicting postoperative acute kidney injury after acute type A aortic dissection.Renal failure · 2025Article
- Prognostic Value of Blood Urea Nitrogen to Albumin Ratio in Elderly Critically Ill Patients with Acute Kidney Injury: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2025Article
- Association between the blood urea nitrogen to serum albumin ratio and the risk of mortality in patients with chronic kidney disease: a cohort study.BMC nephrology · 2025Article
- The predictive value of the serum creatinine-to-albumin ratio (sCAR) and lactate dehydrogenase-to-albumin ratio (LAR) in sepsis-related persistent severe acute kidney injury.European journal of medical research · 2025Article
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- Association of the blood urea nitrogen to serum albumin ratio and 28-day all-cause mortality in patients with cardiac arrest: a retrospective cohort study using the MIMIC-IV database.Frontiers in cardiovascular medicine · 2025Article
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- Article
- Machine learning models for mortality prediction in critically ill patients with acute pancreatitis-associated acute kidney injury.Clinical kidney journal · 2024Article
- Blood urea nitrogen to serum albumin ratio as a new prognostic indicator in type 2 diabetes mellitus patients with chronic kidney disease.Scientific reports · 2024Article
- Association of the blood urea nitrogen to serum albumin ratio and all-cause mortality in critical ill acute ischemic stroke patients: a retrospective cohort study of MIMIC-IV database 3.0.Frontiers in nutrition · 2024Article
- The Interrelation of Blood Urea Nitrogen-to-Albumin Ratio with Three-Month Clinical Outcomes in Acute Ischemic Stroke Cases: A Secondary Analytical Exploration Derived from a Prospective Cohort Study.International journal of general medicine · 2024Article
- Association between blood urea nitrogen to serum albumin ratio and in-hospital mortality in critical patients with diabetic ketoacidosis: a retrospective analysis of the eICU database.Frontiers in endocrinology · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe sought to evaluate the prognostic ability of blood urea nitrogen to serum albumin ratio (BAR) for acute kidney injury (AKI) and in-hospital mortality in patients with intracerebral haemorrhage (ICH) in intensive care unit (ICU).
designA retrospective cohort study using propensity score matching.
settingICU of Beth Israel Deaconess Medical Center.
participantsThe data of patients with ICH were obtained from the Medical Information Mart for Intensive Care IV (V.1.0) database. A total of 1510 patients with ICH were enrolled in our study. MAIN OUTCOME AND MEASURE: The optimal threshold value of BAR is determined by the means of X-tile software (V.3.6.1) and the crude cohort was categorised into two groups on the foundation of the optimal cut-off BAR (6.0 mg/g). Propensity score matching and inverse probability of treatment weighting were performed to control for confounders. The predictive performance of BAR for AKI was tested using univariate and multivariate logistic regression analyses. Multivariate Cox regression analysis was used to investigate the association between BAR and in-hospital mortality.
resultsThe optimal cut-off value for BAR was 6.0 mg/g. After matching, multivariate logistic analysis showed that the high-BAR group had a significantly higher risk of AKI (OR, 2.60; 95% confidence index, 95% CI, 1.86 to 3.65, p<0.001). What's more, a higher BAR was also an independent risk factor for in-hospital mortality (HR, 2.84; 95% confidence index, 95% CI, 1.96 to 4.14, p<0.001) in terms of multivariate Cox regression analysis. These findings were further demonstrated in the validation cohort.
conclusionsBAR is a promising and easily available biomarker that could serve as a prognostic predictor of AKI and in-hospital mortality in patients with ICH in the ICU.
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