Evidence map›Paper›PMID 37607419›Full record

ArticleBrain and language2023

Longitudinal characterization of patients with progressive apraxia of speech without clearly predominant phonetic or prosodic speech features.

Rene L Utianski, Gabriela Meade, Joseph R Duffy, Heather M Clark, Hugo Botha, Mary M Machulda, Dennis W Dickson, Jennifer L Whitwell, Keith A Josephs

Abstract read
In one paragraph

Article in Brain and language, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Word Count Matters: Features of Written Language Production in Progressive Apraxia of Speech with and without Agrammatism.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2025
    Article
  5. Progression of Motor Speech Function in Speakers With Primary Progressive Apraxia of Speech.Journal of speech, language, and hearing research : JSLHR · 2024
    Article
  6. Automatic Speech Recognition in Primary Progressive Apraxia of Speech.Journal of speech, language, and hearing research : JSLHR · 2024
    Article
  7. The yes-no reversal phenomenon in patients with primary progressive apraxia of speech.Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
  8. Characterizing Speech Errors Across Primary Progressive Apraxia of Speech Subtypes.Journal of speech, language, and hearing research : JSLHR · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rene L UtianskiDepartment of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: Utianski.Rene@mayo.edu.
Gabriela MeadeDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Joseph R DuffyDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Heather M ClarkDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Hugo BothaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Mary M MachuldaDepartment of Psychology and Psychiatry, Mayo Clinic, Rochester, MN, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, FL, USA.
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.

Funding

Longitudinal multi-modality imaging in progressive apraxia of speech (Diversity Supplement)R01DC012519 · NIDCD · MAYO CLINIC ROCHESTER · PI Jennifer Louise Whitwell · 2013 to 2026
$7.2M
The neurobiology of two distinct types of progressive apraxia of speechR01DC014942 · NIDCD · MAYO CLINIC ROCHESTER · PI Keith A Josephs, Rene Lynn Utianski · 2017 to 2026
$4.9M
PIB PET Scanning in Speech and Language Based DementiasR01DC010367 · NIDCD · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2014
$1.7M
Assessment of hyperphosphorylated tau PET binding in primary progressive aphasiaR21NS094684 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2016 to 2017
$417k
NIDCD NIH HHS R01 DC010367NIDCD NIH HHS R01 DC012519NIDCD NIH HHS R01 DC014942NINDS NIH HHS R21 NS094684
6 · The paper itself

Abstract

Most recent studies of progressive apraxia of speech (PAOS) have focused on patients with phonetic or prosodic predominant PAOS to understand the implications of the presenting clinical phenotype. Patients without a clearly predominating speech quality, or mixed AOS, have been excluded. Given the implications for disease progression, it is important to understand these patients early in the disease course to inform appropriate education and prognostication. The aim of this study was to describe a cohort of ten patients with initially mixed PAOS and how their clinical course evolves. Four patients were rated prosodic predominant later on (mild AOS at first visit); five were later designated phonetic (four with more than mild AOS at first visit); one was judged mixed at all visits. The study suggests patients without a clear predominance of speech featuresshould still be included in PAOS studies and thought of on the continuum of the disease spectrum.

Indexed as

ApraxiasAgedDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedPhoneticsSpeechSpeech DisordersAphasiaApraxia of speechDegenerativeDysarthriaNeurologic disorders

Identifiers

PMID37607419
PMCPMC10592101

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.