Evidence map›Paper›PMID 37607334›Full record

ArticleInflammatory bowel diseases2024

Extensive Colitis and Smoking Are Associated With Postoperative Complications Within 30 Days of Ileal Pouch-Anal Anastomosis.

Edward L Barnes, Scott Esckilsen, Jean Ashburn, Amy Barto, Richard Bloomfeld, Ashley Cairns, Kurren Mehta, Pooja Patel, Jennifer Dziwis, Michael S Dunn and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Inflammatory bowel diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Edward L BarnesDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0001-9894-8796
Scott EsckilsenDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Jean AshburnDivision of Colon and Rectal Surgery, Atrium Health at Wake Forest Baptist, Winston-Salem, NC, USA.
Amy BartoDivision of Gastroenterology and Hepatology, Duke University, Durham, NC, USA.
Richard BloomfeldSection of Gastroenterology, Atrium Health at Wake Forest Baptist, Winston-Salem, NC, USA.
Ashley CairnsDivision of Colon and Rectal Surgery, Atrium Health at Wake Forest Baptist, Winston-Salem, NC, USA.
Kurren MehtaDepartment of Medicine, Duke University, Durham, NC, USA.
Pooja PatelDepartment of Medicine, Duke University, Durham, NC, USA.
Jennifer DziwisSection of Gastroenterology, Atrium Health at Wake Forest Baptist, Winston-Salem, NC, USA.
Michael S DunnUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Reza RahbarNorth Carolina Surgery, Raleigh, NC, USA.
Timothy S SadiqNorth Carolina Surgery, Raleigh, NC, USA.
John S HansonDivision of Gastroenterology and Hepatology, Atrium Health, Charlotte, NC, USA.
Hans H HerfarthDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.
Atrium Health Wake Forest Baptist · USUniversity of North Carolina at Chapel Hill · USDuke University · USNorth Carolina Clinical Research · USAtrium Medical Cente · US

Funding

Treatment Approaches and Outcomes in Pouch-related Disorders after Colectomy for Ulcerative ColitisK23DK127157 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARNES, EDWARD · 2021 to 2025
$1.0M
NIDDK NIH HHS K23 DK127157NIH HHS K23DK127157-01
6 · The paper itself

Abstract

backgroundOur understanding of outcomes after proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) is largely based on analyses of selected populations. We created a state-level registry to evaluate the epidemiology of IPAA surgery and pouch-related outcomes across the major healthcare systems performing these surgeries in our state.

methodsWe created a retrospective cohort of all patients undergoing restorative proctocolectomy with IPAA for UC at 1 of 4 centers between January 1, 2018, and December 31, 2020. The primary outcomes of this study were the rate of complications and all-cause readmissions within the first 30 days of the final stage of IPAA surgery.

resultsDuring the study period, 177 patients underwent IPAA surgery with 66 (37%) experiencing a complication within 30 days. After adjusting for the number of stages in IPAA surgery, patients with extensive UC (odds ratio, 3.61; 95% confidence interval, 1.39-9.33) and current or former smokers (odds ratio, 2.98; 95% confidence interval, 1.38-6.45) were more likely to experience a complication. Among all patients, 57 (32%) required readmission within 30 days. The most common reasons for readmission were ileus/small bowel obstruction (22%), peripouch abscess (19%), and dehydration (16%).

conclusionIn this first state-level examination of the epidemiology of IPAA for UC, we demonstrated that the complication rate after IPAA for UC was 37%, with one-third of patients being readmitted within 30 days. Extensive disease at the time of colectomy appears to be an indicator of more severe disease and may portend a worse prognosis after IPAA.

Indexed as

Colitis, UlcerativePatient ReadmissionPostoperative ComplicationsProctocolectomy, RestorativeSmokingAdultColonic PouchesFemaleHumansMaleMiddle AgedRegistriesRetrospective StudiesRisk Factorsileal pouch–anal anastomosisJ-pouchoutcomes researchpouchitisreadmission

Identifiers

PMID37607334
PMCPMC11291612
OpenAlexW4386054743

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.