ReviewAngewandte Chemie (International ed. in English)2023
Synthetic Advantages of Defluorinative C-F Bond Functionalization.
Review in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Bayesian optimization- and high-throughput-guided synthesis of monofluoroalkenesChemical science · 2026Article
- Speciation-Controlled C-F Bond Functionalization Enabled by Zwitterionic Pnictinidenes.Angewandte Chemie (International ed. in English) · 2026Article
- Zipper polydefluorination-monoborylation of perfluoroalkyl chains.Nature communications · 2026Article
- Non-decarboxylative C-H Fluorination of Carboxylic Acids by Iridium Photocatalysis.Organic letters · 2026Article
- Selective Electrochemical Defluorinative Hydroxymethylation toward Difluoro-Substituted Alcohol Building Blocks.Organic letters · 2026Article
- Radical "Link-and-Lose" Strategies for Iterative C-F Functionalization of Polyfluoroarenes.Chem · 2026Article
- Conversion of trifluoromethyls into esters along with polyether upcyclingChemical science · 2026Article
- A Brønsted acid-base approach for the net monoselective C-F substitution of (trifluoromethyl)alkanes.Chemical science · 2026Article
- HP(O)PhJACS Au · 2026Article
- Unlocking the reducing power of metal nitrides by mechanochemical hydrodefluorination of fluorinated compounds.Nature communications · 2026Article
- Direct Fluoroformylation of the C3-Position of Indoles with 2,4-Dinitro(trifluoromethoxy)benzene as Fluorocarbonyl Source.ChemistryOpen · 2026Article
- Defluoroalkylation of Trifluoromethane with Organolithium Reagents: Mechanism and Synthesis of Fluoroalkenes.Angewandte Chemie (International ed. in English) · 2026Article
- Stereoselective Synthesis of Alkenyl Fluorides and Alkynes by Defluoro Coupling of Trifluoromethyl Arenes.Angewandte Chemie (International ed. in English) · 2025Article
- Selective Synthesis of α,α-Difluoro- and α-Monofluoro Methylene Substituted Arenes by Defluoro C-C Bond Coupling.Organic letters · 2025Article
- Activation ofThe Journal of organic chemistry · 2025Article
- Copper-Catalyzed Diastereoselective Defluoroborylation of Pentafluoroethyl Alkenes Using (pin)B-B(dan).Organic letters · 2025Article
- Article
- Palladium-Catalyzed Allylic C-F Bond Functionalization of Pentafluoroethyl Alkenes with Heteroatom Nucleophiles.Organic letters · 2025Article
- Catalytic Oxidation of Carbon-Halogen Bonds by Water with HJournal of the American Chemical Society · 2025Article
- Linking Fluorine with Bio-Derived Furfural: Aiming Towards More Sustainable Fluorinated Polymers and Drugs.Molecules (Basel, Switzerland) · 2025Review
Corrections and comments
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2 authors.
Funding
Abstract
Much progress has been made in the development of methods to both create compounds that contain C-F bonds and to functionalize C-F bonds. As such, C-F bonds are becoming common and versatile synthetic functional handles. This review summarizes the advantages of defluorinative functionalization reactions for small molecule synthesis. The coverage is organized by the type of carbon framework the fluorine is attached to for mono- and polyfluorinated motifs. The main challenges, opportunities and advances of defluorinative functionalization are discussed for each class of organofluorine. Most of the text focuses on case studies that illustrate how defluorofunctionalization can improve routes to synthetic targets or how the properties of C-F bonds enable unique mechanisms and reactions. The broader goal is to showcase the opportunities for incorporating and exploiting C-F bonds in the design of synthetic routes, improvement of specific reactions and advent of new methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.