Article in The Journal of experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 1 citations in OpenAlex.
Dominic J AcriStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0003-1942-0892
Yanwen YouStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-5168-9720
Mason D TateStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-8967-4006
Hande KarahanStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0003-3192-7362
Pablo MartinezDepartment of Anatomy, Cell Biology and Physiology, Indiana UniversitySchool of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-3496-4652
Brianne McCordStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0003-4532-4044
A Daniel SharifyStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0009-0004-8762-6977
Sutha JohnStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-4642-9174
Byungwook KimStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0001-8390-7713
Luke C DabinStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0001-6365-291X
Stéphanie PhiltjensStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-8004-2088
H R Sagara WijeratneStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-8209-5626
Tyler J McCrayStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-2070-6540
Daniel C SmithStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-2910-6533
Stephanie J BisselStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-7376-2327
Bruce T LambStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0001-8507-2561
Cristian A Lasagna-ReevesStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-5499-3082
Jungsu KimStark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN, USA.ORCID 0000-0002-6931-8581
University of Indianapolis · US
Funding
Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
RESEARCH TRAINING PROGRAM IN DIABETES AND OBESITYT32DK064466 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Carmella Evans-Molina, RONALD C WEK · 2003 to 2026
$5.2M
Novel genetic modifiers of C9orf72 and Tau toxicityRF1AG062077 · NIA · MAYO CLINIC ARIZONA · PI FRYER, JOHN DAVID, PETRUCELLI, LEONARD · 2019 to 2019
$4.0M
Indiana Medical Scientist/Engineer Training ProgramT32GM148382 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Benjamin Gaston, Emily K Sims · 2023 to 2026
$3.9M
The role of ABI3 in Alzheimers diseaseR01AG071281 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KIM, JUNGSU · 2021 to 2025
$3.7M
Molecular genetic analyses of transcriptional dysregulation in Alzheimers diseaseR01AG077829 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Jungsu Kim · 2022 to 2026
$3.6M
Tau-seed protein interactome and its role in neurodegenerative tauopathiesR01NS119280 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI LASAGNA-REEVES, CRISTIAN · 2020 to 2024
$3.5M
Training Grant on Alzheimer's Disease and ADRD at Indiana UniversityT32AG071444 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GARY E. LANDRETH, Bruce T Lamb · 2021 to 2026
$2.8M
The role of ABI3 in Alzheimers diseaseRF1AG074543 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KIM, JUNGSU · 2021 to 2021
$2.3M
Generation of Abi3 conditional knockout mouse modelR21AG072738 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KIM, JUNGSU · 2021 to 2021
$432k
Proteomic and functional analysis of missense variants of APOE associated with Alzheimer disease riskF30AG079580 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI WIJERATNE, HR SAGARA · 2022 to 2025
$159k
The role of micro-RNA-33 in Tau pathologyF31AG074673 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI TATE, MASON DOUGLAS · 2022 to 2023
Previous research demonstrated that genetic heterogeneity is a critical factor in modeling amyloid accumulation and other Alzheimer's disease phenotypes. However, it is unknown what mechanisms underlie these effects of genetic background on modeling tau aggregate-driven pathogenicity. In this study, we induced tau aggregation in wild-derived mice by expressing MAPT. To investigate the effect of genetic background on the action of tau aggregates, we performed RNA sequencing with brains of C57BL/6J, CAST/EiJ, PWK/PhJ, and WSB/EiJ mice (n = 64) and determined core transcriptional signature conserved in all genetic backgrounds and signature unique to wild-derived backgrounds. By measuring tau seeding activity using the cortex, we identified 19 key genes associated with tau seeding and amyloid response. Interestingly, microglial pathways were strongly associated with tau seeding activity in CAST/EiJ and PWK/PhJ backgrounds. Collectively, our study demonstrates that mouse genetic context affects tau-mediated alteration of transcriptome and tau seeding. The gene modules associated with tau seeding provide an important resource to better model tauopathy.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Network analysis identifies strain-dependent response to tau and tau seeding-associated genes. · full record | OpenQuestion