Evidence map›Paper›PMID 37606854›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2024

First long-term outcome data for the MicraVR™ transcatheter pacing system: data from the largest prospective German cohort.

Arian Sultan, Cornelia Scheurlen, Jonas Wörmann, Jan-Hendrik van den Bruck, Karlo Filipovic, Susanne Erlhöfer, Sebastian Dittrich, Jan-Hendrik Schipper, Jakob Lüker, Jan-Malte Sinning and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. [Leadless cardiac pacemaker : Overview, tips, and tricks].Herzschrittmachertherapie & Elektrophysiologie · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arian Sultan *Department of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany. arian.sultan@uk-koeln.de.ORCID http://orcid.org/0000-0003-1807-4860
Cornelia Scheurlen *Department of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Jonas WörmannDepartment of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Jan-Hendrik van den BruckDepartment of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Karlo FilipovicDepartment of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Susanne ErlhöferDepartment of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Sebastian DittrichDepartment of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Jan-Hendrik SchipperDepartment of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Jakob LükerDepartment of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Jan-Malte SinningSt. Vinzenz Hospital Cologne, Cologne, Germany.
Dinh Quang NguyenSt. Vinzenz Hospital Cologne, Cologne, Germany.
Sören FischerSt. Vinzenz Hospital Cologne, Cologne, Germany.
Daniel Steven *Department of Electrophysiology, Heart Center, University of Cologne, Cologne, Germany, Kerpener Str. 62, 50937, Cologne, Germany.
Stefan Winter *St. Vinzenz Hospital Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe MicraVR™ transcatheter pacing system (TPS) has been implemented into clinical routine for several years. The primary recipients are patients in need for VVI pacing due to bradycardia in the setting of atrial fibrillation (AF). Implantation safety and acute success have been proven in controlled studies and registries. So far only few long-term real-life data on TPS exist. We report indication, procedure and outcome data from two high-volume implanting German centers.

methodsBetween 2016 and 2019, 188 (of 303) patients were included. During follow-up (FU), TPS interrogation was performed after 4 weeks and thereafter every 6 months.

resultsIndication for TPS implantation in 159/188 (85%) patients was permanent or intermittent AV block III° in the setting of atrial fibrillation. The mean procedure duration was 50 min [35.0-70.0]. The average acute values after system release were: thresholds: 0.5V [0.38-0.74]/0.24ms; R-wave sensing: 10.0mV [8.1-13.5]; impedance: 650 Ohm [550-783]; RV-pacing demand: 16.9% [0.9-75.9]; and battery status: 3.15 V [3.12-3.16]. During FU of 723.4 ± 597.9 days, neither pacemaker failure nor infections were reported. Long-term FU revealed: thresholds: 0.5V [0.38-0.63]/0.24 ms; sensing: 12.3mV [8.9-17.2]; impedance: 570 Ohm [488-633]; RV-pacing demand: 87.1% [29.5-98.6]; and battery status 3.02 V [3.0-3.1]. Forty-three patients died from not-device-related causes.

conclusionThis to date largest German long-term dataset for MicraVR™ TPS implantation revealed stable device parameter. Foremost, battery longevity seems to fulfill predicted values despite a significant increase in RV-pacing demand over time and even in patients with consecutive AV-node ablation. Of note, no infections or system failure were observed.

Indexed as

Atrial FibrillationCardiac Pacing, ArtificialAgedAged, 80 and overAtrioventricular BlockBradycardiaCardiac CatheterizationFemaleFollow-Up StudiesGermanyHumansMaleMiddle AgedPacemaker, ArtificialProspective StudiesTime FactorsComplicationsIndicationsLeadless pacerLong-term follow-upOutside registry experience

Identifiers

PMID37606854
PMCPMC11420340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.