Evidence map›Paper›PMID 37606476›Full record

ArticleDiseases (Basel, Switzerland)2023

A Mixture of Essential Oils from Three Cretan Aromatic Plants Inhibits SARS-CoV-2 Proliferation: A Proof-of-Concept Intervention Study in Ambulatory Patients.

Christos Lionis, Elena Petelos, Manolis Linardakis, Athanasios Diamantakis, Emmanouil Symvoulakis, Maria-Nefeli Karkana, Marilena Kampa, Stergios A Pirintsos, George Sourvinos, Elias Castanas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diseases (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Christos LionisClinic of Social and Family Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0002-9324-2839
Elena PetelosClinic of Social and Family Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0001-8838-7470
Manolis LinardakisClinic of Social and Family Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0003-3849-3907
Athanasios DiamantakisClinic of Social and Family Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Emmanouil SymvoulakisClinic of Social and Family Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Maria-Nefeli KarkanaClinic of Social and Family Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0002-5394-8087
Marilena KampaLaboratory of Experimental Endocrinology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Stergios A PirintsosDepartment of Biology, School of Sciences and Technology, University of Crete, 71003 Heraklion, Greece.
George SourvinosLaboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Elias CastanasLaboratory of Experimental Endocrinology, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0002-8370-1835
University of Crete · GRLinköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe need for effective therapeutic regimens for non-critically ill patients during the COVID-19 pandemic remained largely unmet. Previous work has shown that a combination of three aromatic plants' essential oils (CAPeo) (

methodsA total of 69 adult patients were included in a clinical proof-of-concept (PoC) intervention study. Family physicians implemented the observational study in two arms (intervention group and control group) during three study periods (IG

resultsThe PoC study found that the number and frequency of general symptoms, including general fatigue, weakness, fever, and myalgia, decreased following CAPeo administration. By Day 7, the average presence (number) of symptoms decreased in comparison with Day 1 in IG (4.7 to 1.4) as well as in CG (4.0 to 3.1), representing a significant decrease in the cumulative presence in IC (-3.3 vs. -0.9, DISCUSSION/

conclusionsOur findings suggest that CAPeo possesses potent antiviral activity against SARS-CoV-2 in addition tο its effect against influenza A and B and human rhinovirus HRV14 strains. The early and effective impact on alleviating key symptoms of COVID-19 may suggest this mixture can act as a complementary natural agent for patients with mild COVID-19.

Indexed as

COVID-19effectivenessessential oilsnatural productsSARS-CoV-2

Identifiers

PMID37606476
PMCPMC10443288
OpenAlexW4385690107

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.