Evidence map›Paper›PMID 37606393›Full record

ReviewNeurology international2023

Investigating the Predictive Value of Thyroid Hormone Levels for Stroke Prognosis.

Aimilios Gkantzios, Vaia Karapepera, Dimitrios Tsiptsios, Eirini Liaptsi, Foteini Christidi, Elena Gkartzonika, Stella Karatzetzou, Christos Kokkotis, Mihail Kyrtsopoulos, Anna Tsiakiri and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in Neurology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Observational
  3. Outcomes of acute ischemic stroke in patients with hypothyroidism: A population-based cross-sectional study of 388,000 patients.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  4. Autonomic dysfunction after stroke: an overview of recent clinical evidence and perspectives on therapeutic management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Lower Free T3 Levels Linked to Poorer Outcomes in Chronic Obstructive Pulmonary Disease Patients with Acute Hypercapnic Respiratory Failure.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Aimilios GkantziosNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-0890-4069
Vaia KarapeperaNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Dimitrios TsiptsiosNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-1601-8788
Eirini LiaptsiNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Foteini ChristidiNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Elena GkartzonikaSchool of Philosophy, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-0095-0028
Stella KaratzetzouNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Christos KokkotisDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, Greece.
Mihail KyrtsopoulosNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Anna TsiakiriNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-3341-4093
Paschalina BebeletsiNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Sofia ChaidemenouNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Christos KoutsokostasNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Konstantinos TsamakisKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London SE5 8AF, UK.ORCID 0000-0002-0063-8413
Maria BaltziDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, Greece.
Dimitrios MpalampanosDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, Greece.
Nikolaos AggelousisDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, Greece.ORCID 0000-0001-5108-7335
Konstantinos VadikoliasNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0484-369X
Democritus University of Thrace · GRKing's College London · GBUniversity of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the expansion of life expectancy, the aging of the population, and the anticipated rise in the number of stroke survivors in Europe with severe neurological consequences in the coming decades, stroke is becoming the most prevalent cause of functional disability. Therefore, the prognosis for a stroke must be timely and precise. Two databases (MEDLINE and Scopus) were searched to identify all relevant studies published between 1 January 2005 and 31 December 2022 that investigated the relationship between thyroid hormone levels and acute stroke severity, mortality, and post-hospital prognosis. Only full-text English-language articles were included. This review includes Thirty articles that were traced and incorporated into the present review. Emerging data regarding the potential predictive value of thyroid hormone levels suggests there may be a correlation between low T3 syndrome, subclinical hypothyroidism, and poor stroke outcome, especially in certain age groups. These findings may prove useful for rehabilitation and therapy planning in clinical practice. Serum thyroid hormone concentration measurement is a non-invasive, relatively harmless, and secure screening test that may be useful for this purpose.

Indexed as

blood biomarkersfT3fT4hyperthyroidismhypothyroidismlow-T3-syndromeprognosisstrokeT4thyroid hormonesTSH

Identifiers

PMID37606393
PMCPMC10443262
OpenAlexW4385490513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.