Evidence map›Paper›PMID 37606287›Full record

ArticleUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2023

Characterization of adnexal lesions using photoacoustic imaging to improve sonographic O-RADS risk assessment.

Q Zhu, H Luo, W D Middleton, M Itani, I S Hagemann, A R Hagemann, M J Hoegger, P H Thaker, L M Kuroki, C K McCourt and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Optical and Optoacoustic Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Q ZhuDepartment of Biomedical Engineering, Washington University, St Louis, MO, USA.ORCID 0000-0002-1837-2588
H LuoDepartment of Biomedical Engineering, Washington University, St Louis, MO, USA.
W D MiddletonDepartment of Radiology, Washington University School of Medicine, St Louis, MO, USA.
M ItaniDepartment of Radiology, Washington University School of Medicine, St Louis, MO, USA.
I S HagemannDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
A R HagemannDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.
M J HoeggerDepartment of Radiology, Washington University School of Medicine, St Louis, MO, USA.
P H ThakerDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.
L M KurokiDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.
C K McCourtDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.
D G MutchDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.
M A PowellDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.
C L SiegelDepartment of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Washington University in St. Louis · US

Funding

Coregistered Photoacoustic and Ultrasound Imaging for Ovarian Cancer Diagnosis and Risk ManagementR01CA237664 · NCI · WASHINGTON UNIVERSITY · PI POWELL, MATTHEW A, SIEGEL, CARY L · 2020 to 2024
$2.6M
Co-registered photoacoustic and ultrasound imaging for non-invasive ovarian canR01CA151570 · NCI · WASHINGTON UNIVERSITY · PI BREWER, MOLLY A., ZHU, QUING · 2011 to 2015
$1.6M
NCI NIH HHS R01 CA151570NCI NIH HHS R01 CA237664NCI NIH HHS R01CA237664
6 · The paper itself

Abstract

objectiveTo assess the impact of photoacoustic imaging (PAI) on the assessment of ovarian/adnexal lesion(s) of different risk categories using the sonographic ovarian-adnexal imaging-reporting-data system (O-RADS) in women undergoing planned oophorectomy.

methodThis prospective study enrolled women with ovarian/adnexal lesion(s) suggestive of malignancy referred for oophorectomy. Participants underwent clinical ultrasound (US) examination followed by coregistered US and PAI prior to oophorectomy. Each ovarian/adnexal lesion was graded by two radiologists using the US O-RADS scale. PAI was used to compute relative total hemoglobin concentration (rHbT) and blood oxygenation saturation (%sO

resultsThere were 93 lesions identified on imaging among 68 women (mean age, 52 (range, 21-79) years). Surgical pathology revealed 14 patients with malignant ovarian/adnexal lesion, two with malignant Fallopian tube only and 52 with benign findings. rHbT was significantly higher in malignant compared with benign lesions. %sO

conclusionsIncorporating the additional information provided by PAI-derived rHbT and %sO

Indexed as

Adnexal DiseasesOvarian NeoplasmsPhotoacoustic TechniquesCA-125 AntigenFemaleHumansMiddle AgedProspective StudiesRetrospective StudiesRisk AssessmentSensitivity and SpecificityUltrasonographyCA-125 Antigencolor Dopplerovarian cancerphotoacoustic imagingultrasound

Identifiers

PMID37606287
PMCPMC10840885
OpenAlexW4386045933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.