ArticleeLife2023
Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in
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In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Repurposing effect of cardiovascular-metabolic drug to increase lifespan: a systematic review of animal studies and current clinical trial progress.Frontiers in pharmacology · 2024Pooled it
- p38 MAPK and MDT-15 mediate SKN-1-dependent metformin-induced protection against mitis group streptococci in Caenorhabditis elegans.GeroScience · 2026Article
- ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways.bioRxiv : the preprint server for biology · 2026Article
- Reductive death is averted by a conserved de novo lipogenic switch.Molecular cell · 2026Article
- Hormetic fasting extends Caenorhabditis elegans lifespan via H3K27 acetylation of lipid catabolism and antioxidant genes.Cell reports · 2026Article
- Peroxisomes orchestrate metabolic flexibility and longevity via an interorganelle cascade.Nature aging · 2026Article
- Multi-omics analysis of the gut-liver axis revealed the effects of different exercise interventions in NAFLD mice.BMC microbiology · 2026Article
- Multi-omics analysis reveals breed-specific differences in the quality and nutrition of goose eggs.Food chemistry: X · 2026Article
- Review
- Lipidomics of polarized macrophages in the human adipose tissue.Scientific reports · 2025Article
- Fundamental role of brain-organ interaction in behavior-driven holistic homeostasis.Fundamental research · 2025Review
- Iron Stress Reprograms Enterocyte Metabolism.Metabolites · 2025Article
- Hormetic nutrient stress promotes longevity by orchestrating histone acetylation on key lipid catabolism and antioxidant defense genes.bioRxiv : the preprint server for biology · 2025Article
- Environmental factors capable of broadly interfering with nutritional lifespan extension paradigms.iScience · 2025Article
- Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity.Aging cell · 2025Article
- Multi-omic analysis of biological aging biomarkers in long-term calorie restriction and endurance exercise practitioners: A cross-sectional study.Aging cell · 2025Article
- Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels inAntioxidants (Basel, Switzerland) · 2025Review
- Detection of organic compounds in freshly ejected ice grains from Enceladus's ocean.Nature astronomy · 2025Article
- Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia.Frontiers in aging neuroscience · 2025Review
- Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 1 country.
Lucydalila Cedillo *Center for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Fasih M Ahsan *Center for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.ORCID 0000-0001-8031-7056
Sainan LiCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.ORCID 0000-0002-1880-6294
Nicole L StuhrLeonard Davis School of Gerontology, University of Southern California, Los Angeles, United States.ORCID 0000-0003-2537-7114
Yifei ZhouCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.ORCID 0000-0003-0088-6262
Yuyao ZhangCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Adebanjo AdedojaCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Luke M MurphyCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.ORCID 0000-0002-2784-6255
Armen YerevanianCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Sinclair EmansCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Khoi DaoDepartment of Medicine and Pharmacology, University of California San Diego, San Diego, United States.
Zhaozhi LiBiomedical Informatics Core, Massachusetts General Hospital and Harvard Medical Schoo, Cambridge, United States.
Nicholas D PetersonProgram in Innate Immunity, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0003-4157-8119
Jeramie WatrousDepartment of Medicine and Pharmacology, University of California San Diego, San Diego, United States.
Mohit JainDepartment of Medicine and Pharmacology, University of California San Diego, San Diego, United States.
Sudeshna DasBiomedical Informatics Core, Massachusetts General Hospital and Harvard Medical Schoo, Cambridge, United States.
Read Pukkila-WorleyProgram in Innate Immunity, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-5340-8294
Sean P CurranLeonard Davis School of Gerontology, University of Southern California, Los Angeles, United States.ORCID 0000-0001-7791-6453
Alexander A SoukasCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States.ORCID 0000-0002-9100-2436
Broad Institute · USUniversity of California San Diego · USMassachusetts General Hospital · USUniversity of Massachusetts Chan Medical School · USUniversity of Southern California · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MUPLIFT: UCLA Postdocs' Longitudinal Investment in Faculty TrainingK12GM106996 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F, VILLANUEVA, CLAUDIO J · 2016 to 2025
$7.1MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron S Leong · 2023 to 2026
$5.4MUSC-Buck Institute Nathan Shock Admin CoreP30AG068345 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI LITHGOW, GORDON J · 2020 to 2024
$5.0MAn Immune Surveillance Network in C. elegansR01AI130289 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PUKKILA-WORLEY, READ · 2017 to 2025
$4.6MGenetic mechanisms of metformin's pro-longevity and anti-cancer effectsR01AG058256 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SOUKAS, ALEXANDER A · 2018 to 2022
$3.0MMitochondrial action of metformin in aging and longevityR01AG069677 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SOUKAS, ALEXANDER A · 2020 to 2024
$2.1MAge-dependent SKN-1/NRF cytoprotection at the cost of metabolic homeostasisR01AG058610 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CURRAN, SEAN P · 2019 to 2023
$2.1MTraining in the Molecular Basis of Autoimmunity and AutoinflammationT32AI132152 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2018 to 2026
$1.6MNIAID NIH HHS T32 AI132152NIA NIH HHS P30 AG068345NIA NIH HHS R01 AG058256NIA NIH HHS R01 AG069677NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK135043NIGMS NIH HHS K12 GM106996NIH HHS K12GM106996NIH HHS P40 OD010440NIH HHS R01AG058259NIH HHS R01AG058610NIH HHS R01AG69677NIH HHS R01AI130289
Abstract
Biguanides, including the world's most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favorable effects of metformin on longevity and on reducing the incidence and morbidity associated with aging-related diseases. Despite this promise, the full spectrum of molecular effectors responsible for these health benefits remains elusive. Through unbiased screening in
Indexed as
AntimalarialsDiabetes Mellitus, Type 2MetforminAnimalsCaenorhabditis elegansEthersEthyl EthersHumansLipidsLongevityAntimalarialsEthersEthyl EthersLipidsMetforminagingC. elegansether lipidsgeneticsgenomicsmetabolismmetformin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.