ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023
Microvascular maturation of the septal capillary layers takes place in parallel to alveolarization in human lungs.
Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- Three-dimensional characteristics of the alveolar capillary network in infant and adult human lungs.Pediatric research · 2025Article
- Morphological and molecular aspects of lung development.Histology and histopathology · 2025Review
- Decoding the tuberculosis puzzle: mechanical factors driving disease progression.Frontiers in tuberculosis · 2025Article
- Article
- Distribution and volume of mitochondria in alveolar epithelial type 1 cells in infant and adult human lungs.Histochemistry and cell biology · 2024Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Primary and secondary septa formed during lung development contain a double-layered capillary network. To improve gas exchange, the capillary network is remodeled into a single-layered one, a process that is called microvascular maturation (MVM). It takes place during classical and continued alveolarization. Classical alveolarization is defined as a formation of new septa from immature septa and continued alveolarization as a formation from mature septa. Until now, MVM was never quantitatively evaluated in human lungs. To correlate alveolarization and MVM, and to determine the transition point from classical to continued alveolarization, the degree of MVM was stereologically estimated. In 12 human lungs (0.1-15 yr), the alveolar surface area of immature and mature septa was estimated stereologically by intersection counting. An MVM-quotient (R
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