Evidence map›Paper›PMID 37605419›Full record

ArticlePharmaceutical nanotechnology2024

An Oxidative Stress Study on Curcumin and NanoCurcumin against Aluminum Phosphide-induced Kidney Injury in Rats: The Role of SIRT1/FOXO3 Signaling Pathway in Nephrotoxicity.

Hassan Ghasemi, Seyde Farnaz Motevali Manesh, Nejat Kheiripour, Sara Soleimani Asl, Ali Fathi Jouzdani, Akram Ranjbar, Mohadeseh Haji Abdolvahab

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Article in Pharmaceutical nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
0.1field-weighted citation impact, top 66% of its field
1 · What the graph read from it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hassan GhasemiDepartment of Clinical Biochemistry, Abadan University of Medical Sciences, Abadan, Iran.
Seyde Farnaz Motevali ManeshStudent Research Committee, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Nejat KheiripourResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Sara Soleimani AslAnatomy Departments, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Ali Fathi JouzdaniStudent Research Committee, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Akram RanjbarDepartment of Pharmacology and Toxicology, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Mohadeseh Haji AbdolvahabRecombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, 1517964311, Iran.
Hamedan University of Medical Sciences · IRKashan University of Medical Sciences · IRMotamed Cancer Institute · IRUniversal Scientific Education and Research Network · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn this study, we have investigated the aluminium phosphide (ALP) toxicity on Renal Function and oxidative stress in kidney tissue of male rats and the possible protective role of Curcumin and nanoCurcumin against ALP-induced nephrotoxicity.

methodsThirty-six adult male rats were divided into 6 groups (n=6). ALP (2 mg/kg oral administration) and control groups received Curcumin and nanoCurcumin (oral administration 100 mg/kg) or without it. After seven days of treatment, kidney parameters, oxidative stress biomarkers, and expression level of sirtuins1 (SIRT1)/Forkhead box protein O1 (FoxO1) pathway genes were evaluated in kidney tissue. In addition, histopathological changes in the kidney tissues were assayed.

resultsIn the ALP group, compared to the control group, lipid peroxidation levels, urea, and creatinine were increased, and total antioxidant capacity and thiol groups decreased significantly

conclusionThe present study showed that ALP intoxication in kidney tissue can induce oxidative damage. Moreover,

Indexed as

CurcuminForkhead Box Protein O3KidneyOxidative StressSignal TransductionSirtuin 1Acute Kidney InjuryAluminum CompoundsAnimalsAntioxidantsLipid PeroxidationMaleNanoparticlesPhosphinesRatsRats, WistarAluminum CompoundsAntioxidantsCurcuminForkhead Box Protein O3FOXO3 protein, ratPhosphinesSirt1 protein, ratSirtuin 1Aluminum phosphidecurcuminkidneymolecular toxicitynanocurcuminoxidative stressSIRT1/FoxO1.

Identifiers

PMID37605419
OpenAlexW4386045804

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.