Evidence map›Paper›PMID 37605410›Full record

ArticleCurrent computer-aided drug design2024

Machine Learning Algorithms Identify Target Genes and the Molecular Mechanism of Matrine against Diffuse Large B-cell Lymphoma.

Yidong Zhu, Zhongping Ning, Ximing Li, Zhikang Lin

Abstract read
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In one paragraph

Article in Current computer-aided drug design, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Computational modelling of aggressive B-cell lymphoma.Biochemical Society transactions · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yidong ZhuDepartment of Traditional Chinese Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Zhongping NingDepartment of Cardiology, Shanghai Pudong New District Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Ximing LiDepartment of Cardiology, Shanghai Pudong New District Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Zhikang LinLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Shanghai University of Traditional Chinese Medicine · CNTongji University · CNShanghai University of Medicine and Health Sciences · CN

Funding

Key Discipline Groups of Shanghai Pudong New Area PWZxq2022-11Peak Discipline Construction of Shanghai Pudong New Area PWYgf2021-04Shanghai Pudong New Area PKJ2021-Y33
6 · The paper itself

Abstract

backgroundDiffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma worldwide. Novel treatment strategies are still needed for this disease.

objectiveThe present study aimed to systematically explore the potential targets and molecular mechanisms of matrine in the treatment of DLBCL.

methodsPotential matrine targets were collected from multiple platforms. Microarray data and clinical characteristics of DLBCL were downloaded from publicly available database. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were applied to identify the hub genes of DLBCL using R software. Then, the shared target genes between matrine and DLBCL were identified as the potential targets of matrine against DLBCL. The least absolute shrinkage and selection operator (LASSO) algorithm was used to determine the final core target genes, which were further verified by molecular docking simulation and receiver operating characteristic (ROC) curve analysis. Functional analysis was also performed to elucidate the potential mechanisms.

resultsA total of 222 matrine target genes and 1269 DLBCL hub genes were obtained through multiple databases and machine learning algorithms. From the nine shared target genes of matrine and DLBCL, five final core target genes, including

conclusionMatrine may target five genes and the PI3K-Akt signaling pathway in DLBCL treatment.

Indexed as

AlkaloidsLymphoma, Large B-Cell, DiffuseMachine LearningMatrinesQuinolizinesAlgorithmsGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMolecular Docking SimulationSignal TransductionAlkaloidsMatrinesQuinolizinesdiffuse large B-cell lymphomamachine learningMatrinemolecular mechanism.PI3K-Akttargeted therapy

Identifiers

PMID37605410
OpenAlexW4386046270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.