Observational studyCritical care (London, England)2023
The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study.
Observational study in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Impact of combined ECMO - CRRT support on patient outcomes and risk factors: a multicenter retrospective study.Renal failure · 2026Article
- ExtracorporeaL life support and Modification Of Hemostasis: the ELMOH trial: hemostatic changes during the first 48 h of VV- and VA-ECMO: a prospective multicenter cohort study.Critical care (London, England) · 2026Article
- Hematological parameter dynamics in critically ill patients treated with oXirisBMC nephrology · 2026Observational
- Anticoagulation with bivalirudin is associated with improved biocompatibility in patients supported on microaxial flow pumps.JTCVS open · 2026Article
- Multimodal characterization of flow-induced thrombus initiation and growth in extracorporeal membrane oxygenation.Scientific reports · 2026Article
- Hemocompatibility of Emergency Bypass System versus Permanent Life Support extracorporeal membrane oxygenation in a propensity score-matched cohort: analysis of hematologic trajectories and transfusion requirements.Journal of Yeungnam medical science · 2026Article
- The international, prospective CytOSorbJournal of intensive medicine · 2025Article
- Incidence, kinetics, and clinical impact of thrombocytopenia in venovenous ECMO: insights from the multicenter observational PROTECMO study.Critical care (London, England) · 2025Observational
- Hemoadsorption in the Management of Septic Shock: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Antithrombotic and Antimicrobial Potential of S -Nitroso-1-Adamantanethiol-Impregnated Extracorporeal Circuit.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025Article
- Between a rock and a hard place: anticoagulation management for ECMO.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Risk factors of thrombocytopenia in adults receiving extracorporeal membrane oxygenation support: A single center retrospective cohort study.Science progressArticle
Corrections and comments
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Authors and funding
30 authors at 18 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThrombocytopenia, hemorrhage and platelet transfusion are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA ECMO). However, current literature is limited to small single-center experiences with high degrees of heterogeneity. Therefore, we aimed to ascertain in a multicenter study the course and occurrence rate of thrombocytopenia, and to assess the association between thrombocytopenia, hemorrhage and platelet transfusion during VA ECMO.
methodsThis was a sub-study of a multicenter (N = 16) study on transfusion practices in patients on VA ECMO, in which a retrospective cohort (Jan-2018-Jul-2019) focusing on platelets was selected. The primary outcome was thrombocytopenia during VA ECMO, defined as mild (100-150·10
resultsOf the 419 patients included, median platelet count at admission was 179·10
conclusionsThrombocytopenia has a higher occurrence than is currently recognized. Severe thrombocytopenia is strongly associated with platelet transfusion. Future studies should focus on the etiology of severe thrombocytopenia during ECMO, as well as identifying indications and platelet thresholds for transfusion in the absence of bleeding.
trial registrationThis study was registered at the Netherlands Trial Registry at February 26th, 2020 with number NL8413 and can currently be found at https://trialsearch.who.int/Trial2.aspx?TrialID=NL8413.
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