ArticleMolecular brain2023
Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain.
Article in Molecular brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Whole-Brain Monosynaptic Inputs to and Axonal Projections From Posterior Insular Cortex GABAergic Neurons in Mice.CNS neuroscience & therapeutics · 2026Article
- Disgust Propensity, Not Disgust Sensitivity, Shapes the Reactivity of a Subjective Disgust Circuit in Humans.Human brain mapping · 2026Article
- Neuroplasticity-Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain.Brain and behavior · 2026Review
- A Novel Investigation of an In-Scanner Alternative to the Cold Pressor Test in Healthy Individuals.Human brain mapping · 2025Article
- Article
- Disruptions in cortical circuit connectivity distinguish widespread hyperalgesia from localized pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Multiple Posterior Insula Projections to the Brainstem Descending Pain Modulatory System.International journal of molecular sciences · 2024Article
- The Locus Coeruleus in Chronic Pain.International journal of molecular sciences · 2024Review
- Uncovering Interoceptive Human Insular Lobe Function through Intraoperative Cortical Stimulation-A Review.Brain sciences · 2024Review
- Acupuncture for radicular pain: a review of analgesic mechanism.Frontiers in molecular neuroscience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in neuropathic pain states. Here, we aimed to study inhibitory parvalbumin positive (PV+) posterior insula (pIC) to posterior ACC (pACC) projections, and to evaluate the effects of direct optogenetic manipulation of such projections on mechanical nociception and spontaneous ongoing pain in mice with Spared Nerve Injury (SNI). CTB
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.