Evidence map›Paper›PMID 37605216›Full record

ArticleJournal of eating disorders2023

Investigation of brain iron in anorexia nervosa, a quantitative susceptibility mapping study.

Parsa Ravanfar, R Jarrett Rushmore, Amanda E Lyall, Vanessa Cropley, Nikos Makris, Patricia Desmond, Dennis Velakoulis, Martha E Shenton, Ashley I Bush, Susan L Rossell and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of eating disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Parsa RavanfarMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Royal Melbourne Hospital, Level 3, Alan Gilbert Building, 161 Barry ST, Carlton South, VIC, 3053, Australia. sravanfar@student.unimelb.edu.au.
R Jarrett RushmorePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Amanda E LyallPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Vanessa CropleyMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Royal Melbourne Hospital, Level 3, Alan Gilbert Building, 161 Barry ST, Carlton South, VIC, 3053, Australia.
Nikos MakrisPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Patricia DesmondDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Dennis VelakoulisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Royal Melbourne Hospital, Level 3, Alan Gilbert Building, 161 Barry ST, Carlton South, VIC, 3053, Australia.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ashley I BushMelbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Susan L RossellCentre for Mental Health and Brain Sciences, Swinburne University, Hawthorn, VIC, Australia.
Christos PantelisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Royal Melbourne Hospital, Level 3, Alan Gilbert Building, 161 Barry ST, Carlton South, VIC, 3053, Australia.
Warda T Syeda *Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Royal Melbourne Hospital, Level 3, Alan Gilbert Building, 161 Barry ST, Carlton South, VIC, 3053, Australia.
Andrea Phillipou *Department of Mental Health, St Vincent's Hospital, Melbourne, VIC, Australia.
The Royal Melbourne Hospital · AUMassachusetts General Hospital · USBrigham and Women's Hospital · USFlorey Institute of Neuroscience and Mental Health · AUHarvard University · USSt Vincent's Hospital · AUSwinburne University of Technology · AUUniversity of Melbourne · AU

Funding

Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5M
Human Connectome Project for Early PsychosisU01MH109977 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BREIER, ALAN, SHENTON, MARTHA E. · 2016 to 2020
$5.5M
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1M
High Resolution, Comprehensive Atlases of the Human Brain MorphologyR01MH112748 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN, KUBICKI, MAREK · 2018 to 2022
$4.1M
Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCDR01MH111917 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGHERTY, DARIN D, MAKRIS, NIKOLAOS · 2017 to 2019
$2.1M
Mentoring and Neuroimaging Research on White Matter Pathology in SchizophreniaK24MH110807 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2017 to 2021
$945k
Neuroimaging of the Biological Correlates of Early Psychosis: A MR-PET StudyK01MH115247 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI LYALL, AMANDA ELLIS · 2018 to 2022
$889k
Mentoring and neuroimaging research on new targets for DBS in OCDK24MH116366 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MAKRIS, NIKOLAOS · 2018 to 2022
$817k
Modulating Inhibitory Control Networks In Gambling Disorder With Theta Burst StimulationR21DA042271 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, MAKRIS, NIKOLAOS · 2017 to 2018
$439k
NIA NIH HHS R01 AG042512NIDA NIH HHS R21 DA042271NIH HHS R01MH125860NIMH NIH HHS 1K01MH115247-01A1NIMH NIH HHS 5 U01MH109977NIMH NIH HHS K01 MH115247NIMH NIH HHS K24 MH110807NIMH NIH HHS K24 MH116366NIMH NIH HHS R01 MH111917NIMH NIH HHS R01 MH112748NIMH NIH HHS R01MH112748NIMH NIH HHS R01 MH125860NIMH NIH HHS U01 MH109977
6 · The paper itself

Abstract

backgroundAnorexia nervosa (AN) is a potentially fatal psychiatric condition, associated with structural brain changes such as gray matter volume loss. The pathophysiological mechanisms for these changes are not yet fully understood. Iron is a crucial element in the development and function of the brain. Considering the systemic alterations in iron homeostasis in AN, we hypothesized that brain iron would be altered as a possible factor associated with structural brain changes in AN.

methodsIn this study, we used quantitative susceptibility mapping (QSM) magnetic resonance imaging to investigate brain iron in current AN (c-AN) and weight-restored AN compared with healthy individuals. Whole-brain voxel wise comparison was used to probe areas with possible group differences. Further, the thalamus, caudate nucleus, putamen, nucleus accumbens, hippocampus, and amygdala were selected as the regions of interest (ROIs) for ROI-based comparison of mean QSM values.

resultsWhole-brain voxel-wise and ROI-based comparison of QSM did not reveal any differences between groups. Exploratory analyses revealed a correlation between higher regional QSM (higher iron) and lower body mass index, higher illness severity, longer illness duration, and younger age at onset in the c-AN group.

conclusionsThis study did not find evidence of altered brain iron in AN compared to healthy individuals. However, the correlations between clinical variables and QSM suggest a link between brain iron and weight status or biological processes in AN, which warrants further investigation.

Indexed as

Anorexia nervosaBrainIronMagnetic resonance imagingQuantitative susceptibility mapping

Identifiers

PMID37605216
PMCPMC10441741
OpenAlexW4386032915

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.