Evidence map›Paper›PMID 37605205›Full record

ArticleItalian journal of pediatrics2023

Role of luteinizing hormone urinary levels in the diagnostic and therapeutic management of female central precocious puberty.

Ilaria Brambilla, Carmen Guarracino, Carmelo Pistone, Catherine Klersy, Amelia Licari, Gian Luigi Marseglia, Enrico Tondina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ilaria BrambillaPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, p.le C. Golgi 19, Pavia, 27100, Italy. i.brambilla@smatteo.pv.it.ORCID http://orcid.org/0000-0002-7139-6060
Carmen GuarracinoPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, p.le C. Golgi 19, Pavia, 27100, Italy.
Carmelo PistonePediatric Clinic, Fondazione IRCCS Policlinico San Matteo, p.le C. Golgi 19, Pavia, 27100, Italy.
Catherine KlersyDepartment of Epidemiology and Biostatistics, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Amelia LicariPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, p.le C. Golgi 19, Pavia, 27100, Italy.
Gian Luigi MarsegliaPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, p.le C. Golgi 19, Pavia, 27100, Italy.
Enrico TondinaDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, Pediatric Unit, University of Pavia, Pavia, Italy.
Policlinico San Matteo Fondazione · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiagnosing central precocious puberty (CPP) requires an integrated approach based on clinical, biochemical and instrumental data. The diagnostic gold standard is represented by GnRH (gonadotropin-releasing hormone) stimulation test. Some undoubted limitations of this procedure led the international scientific community to look for cheaper and less invasive alternative diagnostic methods, such as luteinizing hormone urinary levels (uLH) measurement. This study aims to define the reliability of urinary LH levels as a biomarker of pubertal development, both concerning the initial diagnostic management and the monitoring of patients with central precocious puberty undergoing therapy with GnRH analogues. Furthermore, the study plans to detect the potential association between LH peak serum (pLH) and urinary LH in patients undergoing diagnostic tests with GnRH and to identify a possible cut-off of uLH that may be suggestive of ensued successful hormonal stimulation.

methodsThe study includes 130 female patients with suspected precocious puberty or in follow-up during suppressive therapy. After the collection of the informed consent, the patients underwent clinical evaluation, auxological assessment, and hormone assays (basal levels of LH, FSH, and oestradiol; GnRH stimulating test in patients with suspected precocious puberty; urinary LH assay on the first-morning urine sample, collected after waking up).

resultsTwo uLH cut-off values have been identified: the first of 0.25 UI/L [C.I. 95% 0.23-0.27], able to distinguish between pubertal and pre-pubertal patients, the second of 0.45 UI/L [C.I. 95% 0,20 - 0,70] suggestive of occurred hormonal stimulation in patients with diagnosis of CPP at GnRH test. All 30 patients with CPP in follow-up during suppressive therapy presented uLH values ≤ 0.45 IU/L (p

conclusionsuLH assays on the first morning urine specimen could be considered a low-cost and minimally invasive tool for precocious puberty diagnosing and monitoring, making possible to be easily performed even by a general pediatrician. Thus, this could help referring only selected patients to pediatric endocrinologists. After an appropriate validation, this approach could reasonably reduce hospital attendance and costs of performing more invasive procedures, with a more significant emotional impact on the pediatric patient.

Indexed as

Puberty, PrecociousUrinary TractChildFemaleGonadotropin-Releasing HormoneHumansLuteinizing HormoneReproducibility of ResultsGonadotropin-Releasing HormoneLuteinizing HormoneCentral precocious pubertyDiagnosisGnRH testLuteinizing hormone urinary levels (uLH)Monitoring

Identifiers

PMID37605205
PMCPMC10441738
OpenAlexW4386026330

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.