Evidence map›Paper›PMID 37605140›Full record

ArticleBMC infectious diseases2023

Laboratory indices of hospitalized sickle cell disease patients, prevalence and antimicrobial susceptibility of pathogenic bacterial isolates at MRCG ward in the Gambia.

Mustapha Dibbasey, Mamudou Dahaba, Francess Sarfo, Ida Jallow-Manneh, Buntung Ceesay, Solomon Umukoro, Mouhamadou Fadel Diop, Alfred Amambua-Ngwa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mustapha DibbaseyDepartment of Haematology laboratory, Clinical Laboratory, Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia. mdibbasey@mrc.gm.
Mamudou DahabaDepartment of Haematology laboratory, Clinical Laboratory, Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Francess SarfoDepartment of Haematology laboratory, Clinical Laboratory, Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Ida Jallow-MannehDepartment of Haematology laboratory, Clinical Laboratory, Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Buntung CeesayDepartment of Clinical Microbiology laboratory, Clinical Laboratory, Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Solomon UmukoroClinical Laboratory Department, Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Mouhamadou Fadel DiopDepartment of Data Science, Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Alfred Amambua-NgwaMalaria Biology Group Department, Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
MRC Unit the Gambia · GM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to determine the prevalence of invasive bacterial infections and their antimicrobial resistance patterns in sickle cell disease (SCD) patients admitted at the Medical Research Council the Gambia (MRCG) Ward in the era of PCV and Hib vaccination in the Gambia. METHODS AND

resultsThis study was conducted in the clinical laboratory department of MRCG. We retrospectively generated haematological, and blood culture data from our electronic medical records from 2015 to 2022 of SCD patients admitted to MRCG Ward. Of 380 SCD patients, blood culture was requested only for 159. Of the 159 admitted SCD, 11 patients had qualified positive blood cultures. Five different types of bacterial pathogens were isolated from these positive blood cultures: 4 Staphylococcus aureus, 3 Streptococcus pneumoniae, 2 Salmonella species, 1 Enterococcus species, and 1 Shigella boydii. No episode of bacteremia caused by Haemophilus influenzae type b was identified. The molecular serotyping of the Streptococcus pneumoniae isolates revealed non-vaccine serotypes 10 A, 12 F and 12 F. Penicillin resistance was recorded in two of the three Streptococcus pneumoniae. The Staphylococcus aureus isolates were penicillin resistant but cefoxitin sensitive, hence no methicillin (oxacillin) resistant Staphylococcus aureus was reported. Generally, the isolated pathogens were all sensitive to chloramphenicol, and vancomycin. The haematological indices were not significantly varied between SCD patients with and without microbiologically confirmed bacterial infection.

conclusionStreptococcus pneumoniae and Staphylococcus aureus were the most common cause of bacteremia in these admitted SCD patients. The presence of non-typhoidal Salmonella and Shigella infection coupled with penicillin resistance should be considered during penicillin prophylaxis and empirical treatment regimens for SCD patients and future SCD management policies in the Gambia. The haematological parameters may not be reliable biomarkers in differentiating bacterial from non-bacterial infections in SCD patients.

Indexed as

Anemia, Sickle CellAnti-Infective AgentsBacteremiaMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsGambiaHumansPenicillinsPrevalenceRetrospective StudiesAnti-Infective AgentsPenicillinsAntimicrobial resistance patternsBacteraemiaBacterial infectionsHaematological parametersSickle cell disease

Identifiers

PMID37605140
PMCPMC10464433
OpenAlexW4386046434

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.