Evidence map›Paper›PMID 37605084›Full record

ArticleAnnals of surgical oncology2023

A Novel Injection Protocol Using Voluven®-Assisted Indocyanine Green with Improved Near-Infrared Fluorescence Guidance in Breast Cancer Sentinel Lymph Node Mapping-A Translational Study.

Yung-Chun Hsieh, Kai-Wei Guo, Man-Wen Wang, Shih-Po Su, Yu-Han Syu, Chiun-Sheng Huang, Yang-Hsiang Chan

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06768268 (Advanced Research on ICG Fluorescence Imaging-Guided Surgery Technique Using Mannitol and Voluven as Adjuncts), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06768268 phase1 / phase2enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Advanced Research on ICG Fluorescence Imaging-Guided Surgery Technique Using Mannitol and Voluven as Adjuncts

TypeinterventionalSponsorNational Taiwan University HospitalRan2025 to 2025Enrolled30ConditionsBreast Cancer Early Stage Breast Cancer (Stage 1-3)ArmsVoluven-assisted Indocyanine green fluorescence guided sentinel lymph node biopsy for breast cancer, Mannitol (20%)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yung-Chun HsiehDepartment of Surgery, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan, ROC.
Kai-Wei GuoDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC.
Man-Wen WangDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC.
Shih-Po SuInstitute of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Yu-Han SyuDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC.
Chiun-Sheng HuangDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Yang-Hsiang ChanDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC. yhchan@nycu.edu.tw.ORCID http://orcid.org/0000-0001-6496-2362
National Yang Ming Chiao Tung University · TWNational Taiwan University · TW

Funding

National Science and Technology Council 112-2113-M-A49-029
6 · The paper itself

Abstract

backgroundNear-infrared (NIR) fluorescence-guided surgery with indocyanine green (ICG) has been demonstrated to provide high sensitivity in sentinel lymph node biopsy (SLNB) for breast cancer but has several limitations, such as unstable pharmacokinetics, limited fluorescence brightness, and undesired diffusion to neighboring tissues. This paper investigates the use of Voluven® as the solvent for ICG fluorescence-guided SLNB (ICG-SLNB).

methodsThe photophysical properties of ICG in water and Voluven® were evaluated in laboratory experiments and in a mouse model. Nine patients with early breast cancer underwent subareolar injection of diluted ICG (0.25 mg/ml) for ICG-SLNB. Six of the nine patients received ICG dissolved in Voluven® (ICG:Voluven®), while three were administered ICG dissolved in water (ICG:water); a repetitive injection-observation protocol was followed for all patients. The mapping image quality was evaluated.

resultsLaboratory experiments and in vivo mouse study showed improved fluorescence and better targeting using Voluven® as the solvent. ICG-SLNB with a repetitive injection-observation protocol was successfully performed in all nine patients. ICG:Voluven® administration had an overall better signal-to-background ratio (SBR) in sequential sentinel lymph nodes. The rates of transportation within the lymphatics were also improved using ICG:Voluven® compared with ICG:water.

conclusionsFrom basic research to animal models to in-human trial, our study proposes a repetitive injection-observation technique with ICG:Voluven®, which is characterized by better transportation and more stable mapping quality for ICG-SLNB in breast cancer patients.

Indexed as

Breast NeoplasmsSentinel Lymph NodeAnimalsColoring AgentsFemaleFluorescenceHumansHydroxyethyl Starch DerivativesIndocyanine GreenLymph NodesMiceSentinel Lymph Node BiopsySolventsWaterColoring AgentsHES 130-0.4Hydroxyethyl Starch DerivativesIndocyanine GreenSolventsWater6% hydroxyethyl starchBreast cancerFluorescence-guided surgeryIndocyanine greenNear-infraredPharmacokineticsSentinel lymph node biopsy

Identifiers

PMID37605084
PMCPMC10625936
OpenAlexW4386026076

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.