Evidence map›Paper›PMID 37605014›Full record

ReviewCellular and molecular neurobiology2023

Biosensors, Recent Advances in Determination of BDNF and NfL.

Ahmad Mobed, Saeid Charsouei, Yalda Yazdani, Morad Kohandel Gargari, Ali Ahmadalipour, Seyyedeh Reyhaneh Sadremousavi, Maryam Farrahizadeh, Ali Shahbazi, Maryam Haghani

Abstract readReview
In one paragraph

Review in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
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  8. Article
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  12. Nanobiosensors for procalcitonin (PCT) analysis.Journal of clinical laboratory analysis · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmad MobedNeuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Mobeda@tbzmed.ac.ir.
Saeid CharsoueiFaculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. Scharsouei@tbzmed.ac.ir.
Yalda YazdaniNeuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Morad Kohandel GargariFaculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Ali AhmadalipourNeuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Seyyedeh Reyhaneh SadremousaviFaculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Maryam FarrahizadehFaculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Ali ShahbaziFaculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Maryam HaghaniNeuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Key biomarkers such as Brain Derived Neurotrophic Factor (BDNF) and Neurofilament light chain (NfL) play important roles in the development and progression of many neurological diseases, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. In these clinical conditions, the underlying biomarker processes are markedly heterogeneous. In this context, robust biomarker discovery is of critical importance for screening, early detection, and monitoring of neurological diseases. The difficulty of directly identifying biochemical processes in the central nervous system (CNS) is challenging. In recent years, biomarkers of CNS inflammatory response have been identified in various body fluids such as blood, cerebrospinal fluid, and tears. Furthermore, biotechnology and nanotechnology have facilitated the development of biosensor platforms capable of real-time detection of multiple biomarkers in clinically relevant samples. Biosensing technology is approaching maturity and will be deployed in communities, at which point screening programs and personalized medicine will become a reality. In this multidisciplinary review, our goal is to highlight clinical and current technological advances in the development of multiplex-based solutions for effective diagnosis and monitoring of neuroinflammatory and neurodegenerative diseases. The trend in the detection if BDNF and NfL.

Indexed as

Alzheimer DiseaseMultiple SclerosisNeurodegenerative DiseasesBiomarkersBrain-Derived Neurotrophic FactorHumansNeurofilament ProteinsBiomarkersBrain-Derived Neurotrophic FactorNeurofilament ProteinsBDNFBiosensorsBrainCNSNeurological diseasesNfLUltra-sensitive

Identifiers

PMID37605014
PMCPMC11407714

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.