ArticleNature plants2023
Plastid-localized amino acid metabolism coordinates rice ammonium tolerance and nitrogen use efficiency.
Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Asparagine Synthetase 1 regulates rice seminal root elongation via jasmonic acid metabolism.Plant cell reports · 2026Article
- An Elite Haplotype of Nitrogen-Use-Efficiency Gene LHT5 Enhances Salt Tolerance in Rice.Plant biotechnology journal · 2026Article
- Root system architecture modulates nitrogen uptake and use efficiency, influencing grain yield in rice.Scientific reports · 2026Article
- Effects and mechanisms of microplastic types on plant uptake of per- and polyfluorinated alkyl substances.Eco-Environment & Health · 2026Article
- The transcription factor OsMADS61 positively regulates root elongation and nitrogen use efficiency in rice.Plant communications · 2026Article
- Amino-acid-transporter-mediated assembly of rhizosphere microbiota enhances soil organic nitrogen acquisition in rice.Nature plants · 2026Article
- Regulation of grain protein content by the amino acid permease gene OsAAP4 in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Global variation in plant-beneficial bacteria in soil under pesticide stress.Nature communications · 2025Article
- Effects of Moso Bamboo (Biology · 2025Article
- Amino Acid Regulation in Rice: Integrated Mechanisms and Agricultural Applications.Rice (New York, N.Y.) · 2025Review
- Phenotype Assessment and Putative Mechanisms of Ammonium Toxicity to Plants.International journal of molecular sciences · 2025Review
- Molecular regulation and domestication of parthenocarpy in cucumber.Nature plants · 2025Article
- Down-regulation of the rice HRS1 HOMOLOG3 transcriptional repressor gene due to N deficiency directly co-activates ammonium and phosphate transporter genes.Journal of experimental botany · 2025Article
- Regulatory network of ammonium and nitrate uptake and utilization in rice.Frontiers in plant science · 2025Review
- Site-2 protease Sll0528 interacts with RbcR to regulate carbon/nitrogen homeostasis in the cyanobacteriumFrontiers in microbiology · 2025Article
- Unveiling nitrogen preferences inFrontiers in plant science · 2025Article
- Natural variation in the adjustment of primary metabolism determines ammonium tolerance in the model grass Brachypodium distachyon.Journal of experimental botany · 2024Article
- The elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice.Nature genetics · 2024Article
- Unraveling crop enzymatic browning through integrated omics.Frontiers in plant science · 2024Review
- Advances in auxin synthesis, transport, and signaling in rice: implications for stress resilience and crop improvement.Frontiers in plant science · 2024Review
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
Abstract
Ammonium toxicity affecting plant metabolism and development is a worldwide problem impeding crop production. Remarkably, rice (Oryza sativa L.) favours ammonium as its major nitrogen source in paddy fields. We set up a forward-genetic screen to decipher the molecular mechanisms conferring rice ammonium tolerance and identified rohan showing root hypersensitivity to ammonium due to a missense mutation in an argininosuccinate lyase (ASL)-encoding gene. ASL localizes to plastids and its expression is induced by ammonium. ASL alleviates ammonium-inhibited root elongation by converting the excessive glutamine to arginine. Consequently, arginine leads to auxin accumulation in the root meristem, thereby stimulating root elongation under high ammonium. Furthermore, we identified natural variation in the ASL allele between japonica and indica subspecies explaining their different root sensitivity towards ammonium. Finally, we show that ASL expression positively correlates with root ammonium tolerance and that nitrogen use efficiency and yield can be improved through a gain-of-function approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.